短时受精周期中多原核合子发生率与妊娠结局的关系  

Incidence of polynuclear zygotes and pregnancy rate after short coincubation of gametes in in vitro fertilization

作　　者：徐志鹏[1] 孙海翔[1] 张宁媛[1] 陈林君[1] 王玢[1] 招霞[1] 赵静[1] 

机构地区：[1]南京大学医学院附属鼓楼医院生殖医学中心,江苏南京210008

出　　处：《中华男科学杂志》2012年第9期807-810,共4页National Journal of Andrology

基　　金：国家自然科学基金(81070492)~~

摘　　要：目的:探讨短时受精多原核合子发生率与妊娠结局的关系。方法:回顾性分析本中心2008年1月至2010年12月共3 862例IVF短时受精治疗资料,按多原核合子发生比例分成无多原核、1%～10%、11%～20%、21%～30%、31%～50%、≥51%6组。分别比较6组患者的妊娠率、种植率、流产率。结果:6组患者年龄、促性腺激素使用剂量、E2值、hCG注射日卵泡数(≥14 mm)、获卵数均无显著差异(P>0.05)。当多原核合子比例在0～10%时妊娠率、种植率均高于其他5组,当多原核合子比例≥51%时妊娠率、种植率均略低于其他5组,而流产率高于其他5组,但6组患者间的妊娠率、种植率、流产率均无统计学差异(P>0.05)。结论:当多原核比例≥51%时,妊娠率、种植率有降低趋势,流产率有增高趋势,但差异无显著性,短时受精周期中多原核合子发生率对临床妊娠结局的影响有待进一步研究。Objective： To explore the relationship of the incidence of polynuclear zygotes with clinical pregnancy after short coincubation of gametes in in vitro fertilization（IVF）.Methods： We retrospectively analyzed 3 862 cases of short gamete coincubation IVF,which were divided into six groups according to the percentage of polynuclear zygotes： 0,1-10%,11-20%,21-30%,31-50%,41-50%,and ≥51%.We compared the rates of clinical pregnancy,implantation and abortion among the six groups.Results： No statistically significant differences were found in the patients’ age,dose of gonadotropin,peak E2,number of follicles at the hCG trigger,and number of oocytes retrieved among the six groups.The 1-10% group showed higher rates of pregnancy and implantation,while the ≥51% group exhibited lower rates of pregnancy and implantation but a higher rate of abortion than the other groups,none with significant differences（P〉0.05）.Conclusion： The incidence of polynuclear zygotes after short coincubation of gametes in IVF cannot serve as a prognostic indicator of the outcome of clinical pregnancy.

关 键 词：短时受精 多原核 妊娠率 辅助生殖技术 

分 类 号：R714.8[医药卫生—妇产科学]