大鼠精索静脉曲张模型的制作及变异分析  

Analysis of the variation of rat spermatic vein and the establishment of varicocele model

作　　者：杨栋[1,2,3] 海波[1] 汪隆旺[1] 马彦[1] 韩晓敏[1] 陈朝晖[1] 李兵[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院泌尿外科,武汉430022 [2]郑州大学附属肿瘤医院 [3]河南省肿瘤医院泌尿外科

出　　处：《临床泌尿外科杂志》2012年第10期782-784,共3页Journal of Clinical Urology

摘　　要：目的:观察大鼠睾丸-精索静脉脉管系统解剖及变异情况,探索大鼠精索静脉曲张(varicocele,VC)模型的制作。方法:采用左肾静脉部分结扎法制作80只SD大鼠的VC模型,对模型组及对照组大鼠的睾丸-精索静脉脉管系统进行解剖并绘制图谱。结果:64只成功制成左侧VC模型,平均静脉直径从术前的0.16mm增加到1.3mm。SD大鼠左侧精索静脉走行存在多种类型的变异情况。VC大鼠的睾丸血流由常规的经精索静脉流入下腔静脉变为经3～4个静脉侧枝经膀胱前列腺周围静脉丛流入髂静脉。结论:大鼠VC模型的制作需要考虑多种静脉变异情况,VC使得睾丸静脉血回流通路发生改变。Objective：To study the anatomy and variability of spermatic vein of rats, and to explore the meth ods in establishing rat varicocele model. Method：Experimental varicocele was produced by partial ligation of the left renal vein of rat model. 80 rats were divided into experimental group and control group, which were anatomized systematically, respectively. Anatomical atlas of spermatic vein was generated. Result：Sixty-four experimental varicocele model were successfully created. The average diameter of left spermatic vein was increased from 0.16 mm to 1.3 mm in postoperatively. Variations of spermatic vein were frequently observed. The blood flow of spermatic Vein, which enters the inferior vena cava in ordinary case, was traced to iliac vein through three to four tributary of venous plexus of bladder/prostate. Conclusion：Variations should be considerate in producing rat varicocele.model. Varicocele changes the return path of testicular vein.

关 键 词：精索静脉曲张 动物模型 大鼠 不育 

分 类 号：R697.24[医药卫生—泌尿科学]