306例不全流产孕妇血清TgAb、TPOAb、TSH、TRAb的测定分析  

Determination and Analysis for 306 Cases of Incomplete Abortion Maternal Serum TgAb, TPOAb, TSH, TRAb

作　　者：毛绍蓉 甘佳[1] 唐小玲[1] 王利[1] 汤伟[1] 

机构地区：[1]四川省内江市第二人民医院核医学科,四川内江641003

出　　处：《中国医药指南》2012年第28期9-10,共2页Guide of China Medicine

摘　　要：目的对306例不全流产孕妇血清TgAb、TPOAb、TSH、TRAb测定,分析自身抗体及促甲状腺激素,探讨不全流产原因与孕妇患有自身免疫疾病有关。方法选择2010年7月至2011年12月来我院就诊确诊为不全流产孕妇306例,同时选择106例不同孕周正常孕妇,清晨采静脉血3mL,分离血清,保存在-25℃以下,用LAISON全自动化学发光仪器检测TgAb、TPOAb、TSH,用r放射免疫仪检测TRAb。结果 306例不全流产孕妇血清中TgAb、TPOAb、TSH、TRAb阳性检出率分别是19.9%、26.1%、14.7%、16.9%,总的检出率77.6%。结论不全流产原因与孕妇患有自身免疫性疾病有关,孕前对自身免疫抗体及促甲状腺激素进行检测,对阳性者进行干预,以减少不全流产的发生。Objective To discuss whether the reason of incomplete abortion is relevant to autoimmune antibody through the test of TgAb,TPOAb,TSH,TRAb of the serum of the 306 cases of pregnant women with incomplete abortion and the analysis of autoimmune antibody and thyroid stimulating hormone.Method 306 cases of pregnant women diagnosed with incomplete abortion during July 2010 to December 2011 were selected,meanwhile selecting 106 cases of pregnant women with different normal pregnancy periods.Collect 3mL venous blood of these pregnant women in the morning,separate the serum,store them in the temperature below-25℃,use LAISON full automatic chemiluminescence instrument to test TgAb,TPOAb,TSH,and use radioimmunoassay instrument to test TRAb.Result The positive rates in the serum of the 306 cases of pregnant women with incomplete abortion are 19.9%,26.1%,14.7% and 16.9% respectively and the total detection rate is 77.6%.Conclusion The reason of incomplete abortion is relevant to pregnant women’s autoimmune disease.The test of autoimmune antibody and thyroid stimulating hormone before pregnancy and the intervention to positive patients will reduce the rate of incomplete abortion.

关 键 词：不全流产 TGAB TPOAB TSH TRAB 测定分析 

分 类 号：R446.1[医药卫生—诊断学]