小檗碱治疗多囊卵巢综合征伴胰岛素抵抗的研究  

The Clinical Study of Berberine in Patients with Polycystic Ovarian Syndrome and Insulin Resistance

作　　者：邓海云[1] 魏巍[1] 关源源[1,2] 

机构地区：[1]哈尔滨医科大学,150001 [2]北京协和医院

出　　处：《天津医药》2012年第10期1009-1011,共3页Tianjin Medical Journal

摘　　要：目的:观察小檗碱治疗多囊卵巢综合征(PCOS)的临床疗效。方法:将62例PCOS伴胰岛素抵抗(IR)患者随机分成2组,实验组给予小檗碱+达英-35(Diane-35),对照组给予安慰剂+Diane-35,2组均连续用药3个周期。测量并计算治疗前后体质量指数(BMI)、腰臀比(WHR)、空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)、三酰甘油(TG)、总胆固醇(TC)、C-反应蛋白(CRP)、肿瘤坏死因子(TNF)指标的变化。结果:实验组与对照组相比WHR、FPG、CHOL、TG、HOMA-IR、CRP、TNF均显著下降,差异有统计学意义(P<0.05或P<0.01)。结论:小檗碱能显著改善PCOS患者的向心性肥胖,调节血脂,增加胰岛素敏感性,并可改善慢性炎症。Objective： To study the clinical effect of berberine （BBR） in patients with polycystic ovarian syndrome （PCOS）. Methods：Sixty-two PCOS patients with insulin resistance （IR） were randomly divided into two groups, the experimental group that received BBR＋Diane-35 and control group that received Diane-35 plus placebo. After three mouths of treatment, values of body mass index （BMI）, waist-to-hip ratio （WHR）, fasting plasma glucose （FPG）, insulin resistance index （HOMA-IR）, triglyceride （TG）, total cholesterol （TC）, C-reactive protein （CRP） and tumor necrosis factor （TNF） were observed. Results： Compared with control group, levels of WHR, FPG, CHOL, TG, HOMA-IR, CRP and TNF were.significantly decreased in experimental group （P 〈 0.05 or P 〈 0.01）. Conclusion：Berberine could significantly improve central obesity, regulate blood lipids, increase insulin sensitivity and ameliorate chronic inflammation in patients with PCOS.

关 键 词：多囊卵巢综合征 胰岛素抗药性 小檗碱 炎症 C反应蛋白质 炔雌醇 

分 类 号：R587.1[医药卫生—内分泌]