去肾脏交感神经术对犬高血压及内皮功能的研究  

Effect of Renal Sympathetic Denervation on Endothelial Function in Hypertensive Dogs

作　　者：赵斌[1] 卢成志[2] 张欣[3] 于翔[2] 王彦欧[2] 

机构地区：[1]天津医科大学一中心临床学院,300192 [2]天津市第一中心医院心内科 [3]天津市第一中心医院检验科

出　　处：《天津医药》2012年第10期1037-1039,共3页Tianjin Medical Journal

基　　金：天津市卫生局科技攻关课题(项目编号:10KG218)

摘　　要：目的:探讨高血压病与交感神经兴奋及内皮功能的关系。方法:18只杂种犬随机分为高血压模型组(n=10)和对照组(n=8)。高血压模型组于全身麻醉下手术分离颈动脉和迷走神经后制作高血压模型,对照组同样操作但不制作高血压模型,造模12周后,2组动物都接受去肾脏交感神经术。测量2组术前和术后2、4、10周的平均动脉压(MAP)和血管紧张素Ⅱ(AngⅡ),测量高血压模型组造模前、造模后12周和去神经术后10周的内皮素-1(ET-1)及降钙素基因相关肽(CGRP)。结果:2组术后2、4、10周的MAP和AngⅡ均低于术前,差异有统计学意义(P<0.05或P<0.01)。在高血压模型组,造模后12周ET-1水平较造模前升高,去神经术后又下降;CGRP在造模后12周较造模前下降,去神经术后又上升,差异有统计学意义(P<0.01)。结论:去肾脏交感神经术可明显降低血压,并在一定程度上改善内皮功能。Objective： To explore the relationship between hypertension, renal sympathetic activity and endothelial function in dogs. Methods： Eighteen mongrel dogs were divided into intervention group （n=10） and control group （n=8）. The hypertension model was made in dogs of intervention group. The percutaneous catheter-based radiofrequency was given to dogs in two groups. Values of mean blood pressure （MAP） and angiotensin Ⅱ （AngⅡ） were detected before operation and at 2, 4 and 10 weeks after operation. The changes of endothelin-1 （ET-1） and calcitonin gene related peptide （CGRP） were detected before and 12 weeks after molding, and 10 weeks after denervation. Results：The values of MAP and Ang Ⅱ were significantly lower 2, 4 and 10 weeks after operation than those before operation in two groups （P 〈 0.05 or P 〈 0.01）. The level of ET-1 was higher after 12 weeks in intervention group, but lower after denervation. The level of CGR was significantly lower after 12 weeks in intervention group （P 〈 0.01）, but was significantly increased after denervation （P 〈 0.01）. Conclusion： Renal sympathetic denervation can significantly decrease blood pressure and improve endothelial dysfunction in dogs.

关 键 词：交感神经切除术 高血压 血管紧张素Ⅱ 内皮缩血管肽类 降钙素基因相关肽 平均动脉压内皮素-1 

分 类 号：R441.9[医药卫生—诊断学]