继发性小肠双糖酶缺乏机制探讨  

The study of the influence factors on secondary intestinal disaccharidase deficiency in children

作　　者：张寅[1] 许春娣[1] 蔡威[2] 奚容平[1] 唐金凤[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院儿内科,上海200025 [2]上海交通大学医学院附属新华医院临床营养中心,上海200092

出　　处：《临床儿科杂志》2012年第10期912-915,共4页Journal of Clinical Pediatrics

基　　金：上海市教委资助项目(No.08yz48)

摘　　要：目的分析肠道黏膜损伤以及幽门螺杆菌（H．pylon）感染对小肠双糖酶活性的影响。方法选取因慢性消化道症状而就诊的0-14岁患儿152例，内镜检查获取十二指肠远端黏膜组织，用Dahlqvist＇s方法测定小肠双糖酶活性，快速尿素酶法检测H．pylon感染，胃十二指肠远端黏膜组织的病理学检查。分析比较不同程度肠黏膜损伤、H．pylon感染与患儿的双糖酶活性的变化。结果不同肠黏膜病理分组患儿的小肠双糖酶水平的差异无统计学意义（P〉O．05）；H．pylori感染阳性与阴性患儿的小肠双糖酶活性的差异也无统计学意义（P〉0．05）。结论肠道黏膜损伤以及幽门螺杆菌感染与小肠双糖酶活性无相关性，可能不是导致肠道双糖酶缺乏的主要原因。Objective To analyze the influence of intestinal mucosal injury and Helicobacter Pylori （H.pylori） infection on intestinal disaccharidase activity in children. Methods A total of 152 Children under the age of 14 years with chronic gastroen- terological symptoms were included. Gastroendoscopy was used to obtain distal duodenal mucosa biopsies. The intestinal disac- charidase activities were determined by Dahlqvist＇s method. The presence of H.pylori infection was checked by 13C-UBT. Patho- logical examination was performed in the tissue sample of distal duodenal mucosa. The association of degree of intestinal mucosa injury and H.pylori infection with disaccharidase activity was analyzed. Results The mean levels of intestinal disaccharidase were not different among different intestinal mucosal pathological groups （P〉0.05）, and were not different between H.pylori- infected and uninfected groups （P〉0.05）. Conclusions There is no significant correlation of intestinal disaccharidase enzyme ac- tivity with intestinal mucosal inflammation and H.pylori infection. Intestinal mucosal inflammation and H.pylori infection might not be the main cause of intestinal disaccharidase deficiency.

关 键 词：肠道双糖酶 Dahlqvist’s方法 内镜 幽门螺杆菌 儿童 

分 类 号：R725.7[医药卫生—儿科]