Mechanisms of Prostate Atrophy after LHRH Antagonist Cetrorelix Injection: An Experimental Study in a Rat Model of Benign Prostatic Hyperplasia  

作　　者：杨栋 侯腾 杨雄 马彦 汪隆旺 李兵 

机构地区：[1]Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology [2]Department of Urology, Shenzhen People's Hospital [3]Second Clinical Medical College, Jinan University

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2012年第3期389-395,共7页华中科技大学学报（医学英德文版）

基　　金：supported by a grant from the National Basic Research Program of China(No.2003CB515304);a grant from the National Natural Science Foundation of China(No.30500535)

摘　　要：In the present study, we investigated the roles of TGF-β signaling pathway in a rat benign prostatic hyperplasia （BPH） model treated with cetrorelix. TGF-β1 and c-Myc expression were measured by qRT-PCR and Western blotting in the proximal and distal region of ventral prostatic lobes, respectively. We observed that treatment with cetrorelix led to a significant reduction of ventral prostate weight in a dose-dependent manner. In the proximal region, after cetrorelix treatment, the expression of TGF-β1 was dramatically increased （P〈0.05）, while the expression of c-Myc was significantly decreased （P〈0.05）. In comparison with the control group, the cetrorelix groups had more TUNEL-positive cells. Our findings strongly suggest that the TGF-β signaling pathway may be one of the major causes responsible for prostate volume reduction in BPH rats after cetrorelix treatment.In the present study, we investigated the roles of TGF-β signaling pathway in a rat benign prostatic hyperplasia （BPH） model treated with cetrorelix. TGF-β1 and c-Myc expression were measured by qRT-PCR and Western blotting in the proximal and distal region of ventral prostatic lobes, respectively. We observed that treatment with cetrorelix led to a significant reduction of ventral prostate weight in a dose-dependent manner. In the proximal region, after cetrorelix treatment, the expression of TGF-β1 was dramatically increased （P〈0.05）, while the expression of c-Myc was significantly decreased （P〈0.05）. In comparison with the control group, the cetrorelix groups had more TUNEL-positive cells. Our findings strongly suggest that the TGF-β signaling pathway may be one of the major causes responsible for prostate volume reduction in BPH rats after cetrorelix treatment.

关 键 词：benign prostatic hyperplasia LHRH transforming growth factor-β 

分 类 号：R697.3[医药卫生—泌尿科学]