手术加放疗治疗耳部瘢痕疙瘩的疗效分析  

Efficiency of Combined Surgery and Radiotherapy for Auricular Keloids

作　　者：柯朝阳 曾凡倩 张静 龚桃根 刘明 

机构地区：[1]暨南大学第二临床医学院(深圳市人民医院)耳鼻咽喉科,深圳518020

出　　处：《中华耳科学杂志》2012年第3期368-370,共3页Chinese Journal of Otology

基　　金：深圳市医疗卫生科技计划项目(No:201102150)

摘　　要：目的研究手术加术后放疗对耳部瘢痕疙瘩的治疗效果。方法我科2005年12月～2011年1月收治耳部瘢痕疙瘩患者30例(39耳),全部采用手术切除加术后直线加速器6Mev电子线照射,隔日一次,共5次,每次放射剂量3Gy,总剂量15Gy。结果治疗结束后1年,39侧患耳中治愈32耳(82.1%),有效3耳(7.7%),总有效率为89.7%,有4耳复发,复发率10.3%;至目前已平均随访37.3月,有11耳复发,复发率28.2%,复发的平均发生时间为19.7月。结论手术切除加术后放疗对耳部瘢痕疙瘩的近期治疗效果令人满意,但其远期疗效不容乐观;对耳部瘢痕疙瘩的随访时间应至少在2年以上。Objective To analyze efficacy of surgical removal combined with postoperative radiotherapy for auricular keloids. Methods From December 2005 to January 2011, 30 patients （39 ears） with auricular keloids were treated by surgical removal combined with postoperative radiotherapy. The first exposure of the lesions to 6 Mev electron beam was within 24h after surgery, followed by 5 doses of treatment （3 Gy each） given every other day. Total radiation dose was 15 Gy. Results At one year after the treatment, 32 ears （82.1%） showed complete resolution of lesion, 3 ears （7.7%） showed some responses to the treatment, 4 ears （10.3%） showed relapse of lesion. At this writing （mean follow-up of 37.3 months）, 11 ears （28.2%） showed lesion relapse, with a mean relapse interval of 19.7 months. Conclusion Results of surgical removal with postoperative radiotherapy in treating auricular keloids are satisfying in the short term, but less so in the long term. Reliable assessment of treatment efficacy for auricular keloid necessitates a follow-up time of at least 2 years.

关 键 词：耳瘢痕疙瘩 随访 手术 放射治疗 

分 类 号：R764.1[医药卫生—耳鼻咽喉科]