单侧突发性感音神经性耳聋患者静息状态默认网络的变化  

Changes of resting-state default-mode network functional connectivity in patients with unilateral sudden sensorineural hearing loss

作　　者：季慧[1] 黄志纯[2] 杨明[3] 朱新[2] 孟黎平[1] 李晶[3] 

机构地区：[1]南京医科大学附属南京市妇幼保健院儿童保健科,江苏省210004 [2]东南大学附属中大医院耳鼻咽喉科 [3]东南大学附属中大医院放射科

出　　处：《江苏医药》2012年第19期2246-2249,共4页Jiangsu Medical Journal

基　　金：国家自然科学基金(30070808);东南大学高校基本科研业务费专项资金(3290001504);南京市科技发展计划项目(7990000011)

摘　　要：目的探索单侧突发性感音神经性耳聋(SSNHL)患者静息状态默认网络的改变。方法选取16例重度左侧突发性感音神经性耳聋患者(耳聋组)和16例健康志愿者(对照组)进行静息状态脑功能磁共振扫描,通过时程相关方法检测fMRI数据低频波动信号中以后扣带回为种子区的默认网络,并进行组间比较。结果耳聋组较正常对照组脑功能连接增强的区域为右侧枕中回,耳聋组较正常对照组脑功能连接减弱的区域为右侧额中回。结论 SSNHL患者在静息状态下存在脑默认网络的功能连接异常。Objective To explore the changes of resting-state default-mode network functional connectivity in the patients with unilateral sudden sensorineural hearing loss（SSNHL）. Methods The [MRI scanning in resting-state was performed in 16 severe left side SSNHL patients（group A） and 16 healthy volunteers with normal hearing（group B）. The default-mode network based on seed region of posterior cingulated cortex was extracted from low frequency fluctuation signal in fMRI data using a temporal correlation method and compared between two groups. Results Compared with group B, the brain area with increased functional connectivity in group A was the right middle occipital gyrus,while the brain area with decreased functional connectivity was the right middle frontal gyrus. Conclusion The abnormal funtional connectivity of brain defanlt mode network happens to the SSNHL patients in resting state.

关 键 词：突发性感音神经性聋 磁共振成像 默认网络 

分 类 号：R764[医药卫生—耳鼻咽喉科]