血小板增多症sCD40L及hs-CRP、ESR检测的意义  

Significance of detecting serum sCD40L,hs-CRP and ESR in patients with essential thrombocythemia

作　　者：陈泽[1] 田小平[2] 刘惠杰[1] 王莹[1] 蔡志梅[1] 毛建平[1] 贾韬[1] 薛连国[1] 赵利东[1] 

机构地区：[1]连云港市第一人民医院血液病科,江苏省222002 [2]连云港市第一人民医院检验科,江苏省222002

出　　处：《江苏医药》2012年第19期2278-2279,共2页Jiangsu Medical Journal

摘　　要：目的探讨血小板增多症(ET)患者血清可溶性CD40L(sCD40L)及高敏C-反应蛋白(hs-CRP)、血沉(ESR)之间的关系。方法用ELISA法检测ET患者治疗前、后及健康对照者血清sCD40L,同时检测血清hs-CRP和ESR水平。结果治疗前,ET患者sCD40L为(19.41±5.52)ng/ml,显著高于治疗后及健康对照组[(5.30±4.09)ng/ml及(3.63±0.64)ng/ml](P<0.05)。hs-CRP、ESR在各组间差异无统计学意义。结论 ET患者血清sCD40L水平与血小板数相关,与CRP、ESR无关。ET患者血清sCD40L升高不一定提示炎症反应。Objective To study the relationship between the serum sCD40L and hs-CRP, ESR in patients with essential thrombocythemia. Methods With ELISA, serum sCD40L was measured in 24 patients（group A） with essential thrombocythemia before and after treatment and 24 healthy controls（group B）. hs-CRP and ESR were detected as well. Resoults Serum sCD40L before treatment in group A was （19.41 ± 5.52） ng/ml, which was significantly higher than （5.30±4. 09） ng/ml before and （3. 63±0. 64） ng/ml in group B（P〈0. 05））. The levels of hs-CRP and ESR were not significantly different between groups of A and/3. Conclusion Serum sCIMOL level is closely realted to platelet count,but not to hs-CRP or ESR in the patients with essential thrombocythemia, in whom increased sCD40L may not indicate inflammation response.

关 键 词：血小板增多症 SCD40L 高敏C-反应蛋白 血沉 

分 类 号：R558[医药卫生—血液循环系统疾病]