TAP1基因多态性与新疆地区汉族变应性鼻炎相关性研究  

Relationship between rs1057141 and rs1135216 polymorphisms of TAP1 gene and allergic rhinitis in Xinjiang Han people

作　　者：陈庆勇[1] 刘志连[1] 张华[1] 

机构地区：[1]新疆医科大学第一附属医院耳鼻咽喉科,乌鲁木齐830054

出　　处：《临床耳鼻咽喉头颈外科杂志》2012年第20期917-920,925,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金资助项目(No:30860310)

摘　　要：目的:初步探讨抗原处理相关转运蛋白1(TAP1)基因rs1057141、rs1135216位点多态性与新疆汉族变应性鼻炎(AR)易感性的关系。方法:随机选择新疆医科大学第一附属医院耳鼻咽喉科门诊就诊的无血缘关系的汉族AR患者150例(AR组)和门诊体检健康对照150例(对照组),采用SNaPshot SNP分型技术检测300个样本rs1057141、rs1135216基因位点多态性,并与NCBI基因库中世界其他种族人群进行比较。结果:TAP1*rs1057141基因型G/G、G/A、A/A在AR组中的频率分别为2.70%、33.30%、64.00%,在对照组中的频率分别为4.00%、30.00%、66.00%,2组间基因型频率分布差异无统计学意义(P>0.05)。TAP1*rs1135216基因型G/G、G/A、A/A在AR组中的频率分别为1.30%、27.30%、71.40%,在对照组中的频率分别为2.0%、28.7%、69.3%,2组间基因型频率分布差异无统计学意义(P>0.05)。新疆汉族TAP1*rs1057141、rs1135216基因型及等位基因与世界其他人群相比较,差异均有统计学意义(P<0.05)。结论:TAP1*rs1057141、rs1135216多态性与新疆汉族AR易感性无关。新疆地区汉族人群中TAP1*rs1057141、rs1135216位点基因型频率分布与世界其他种族人群均有差异。Objective：To investigate the association between transporter associated with antigen processing 1 （TAP1） rs1057141 and rs1135216 gene polymorphisms and predisposition to allergic rhinitis（AR） in Xinjiang Han people. Method：A case control study was conducted. The region of the TAP1 ＊ rs1057141 and rs1135216 was studied in 150 Xinjiang Han people with allergic rhinitis and 150 normal controls by using SNaPshot system, and these data were compared with other ethics groups in the world according to the NCBI gene bank. Result：The gen- otypes distribution of the group were in the Hardy-Weinberg equilibrium（P〉0.05）. The frequencies of three gen- otypes（G/G,G/A,A/A） of TAP1 ＊ rs1057141 were 4. 00%, 30. 00%, 66. 00% in controls and 2. 70%, 33. 300/00, 64.00% in AR groups , which showed no difference（P〉0.05）. The frequencies of three genotypes（G/ G,G/A,A/A） of TAP1 ＊ rs1135216 were 2.0% ,28.7% ,69.3% in controls and 1.30%,27.30% ,71.40% in AR groups, which showed no difference either（P〉0.05）. According to the NCBI database, there was difference be tween Xinjiang Han people and other ethnics in the world. Conclusion：Lacking association was found between the mutation of TAP1 ~ rs1057141,rsl135216 gene G allele and allergic rhinitis in the Xinjiang Han people. Maybe TAP1 ＊ rs1057141 ,rs1135216 were not susceptibility genes to AR. And apparent differences existed in TAP1 gene polymorphisms between Xinjiang Han people and other ethnic groups in the world.

关 键 词：鼻炎 变应性 TAP1 基因多态性 汉族 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]