对亚胺培南耐药的铜绿假单胞菌药敏情况分析  

Resistance analysis of pseudomonas aeruginosa resisting to imipenem

作　　者：李小靖[1] 陈武嘉 钟燕玲 

机构地区：[1]广州医学院第四附属医院检验科,广东广州511447 [2]广州市番禺区中心医院检验科,广东广州511400 [3]广州市番禺区慢性病防治站检验科,广东广州511400

出　　处：《中国医药科学》2012年第14期106-107,共2页China Medicine And Pharmacy

摘　　要：目的了解对亚胺培南耐药的铜绿假单胞菌的药敏情况。方法细菌的鉴定及药敏试验均采用法国梅里埃公司的VITEK-2微生物鉴定与药敏系统,选择经VITEK-2测定对亚胺培南耐药的铜绿假单胞菌(耐药株)136株及对亚胺培南敏感的铜绿假单胞菌(敏感株)134株,统计分析两者对丁胺卡那、庆大霉素、头孢他啶、头孢他啶/阿奇霉素、哌拉西林、哌拉西林/他唑巴坦等几种临床上常用抗生素的药敏情况。结果耐药株对以上6种抗生素的敏感率分别为:丁胺卡那20.6%、庆大霉素19.1%、头孢他啶/阿奇霉素70.6%、头孢他啶27.9%、哌拉西林63.2%、哌拉西林/他唑巴坦72.1%;而敏感株对此6种抗生素的敏感率则分别为32.8%、68.7%、92.5%、65.7%、88.1%和89.6%,明显高于耐药株。经x2检验,除丁胺卡那两者比较差异无统计学意义(P>0.05)外,对其余5种抗生素的敏感率两者比较差异有统计学意义(P均<0.05)。结论对亚胺培南耐药的铜绿假单胞菌引起的感染,头孢他啶/阿奇霉素、哌拉西林/他唑巴坦、哌拉西林是较好的选择,而丁胺卡那、庆大霉素及单独使用头孢他啶则不推荐。Objective To investigate the medical resistance of pseudomonas aeruginosa resisting to imipenem.Methods 136 strains of pseudomonas aeruginosa resisting to imipenem were identified and performed the antibiotic sensitivity test by VITKE-2 system.The antibiotic included amikacin,gentamycin,ceftazidime ceftazidime/azithromycin piperacillin,piperacillin/tazobactam.To analyze the medical resistance of 134 strains of pseudomonas aeruginosa sensitive to imipenem in contrast.Results The rates of sensitivity to these six kinds of antibiotics were amikacin 20.6%,gentamycin 19.1%,ceftazidime/azithromycin 70.6%,ceftazidime 27.9%,piperacillin 63.2%,piperacillin/tazobactam 72.1% respectively.These sensitivity rates were apparently lower than the rates of the strains of pseudomonas aeruginosa sensitive to imipenem which were 32.8%,68.7%,92.5%,65.7%,88.1% and 89.6% respectively.There were significant differences during the five kinds of antibiotics（P 0.05） except amikacin（P 0.05） between two kinds of strains of pseudomonas aeruginosa.Conclusion Ceftazidime/azithromycin,piperacillin/tazobactam,and piperacillin would have better effect in treating the infection aroused by pseudomonas aeruginosa resisting to imipenem.But amikacin,gentamycin and ceftazidime are not recommended.

关 键 词：亚胺培南 铜绿假单胞菌 耐药 敏感 

分 类 号：R446.5[医药卫生—诊断学]