血浆PAI-1、Fg与糖尿病肾病的相关性研究  

Correlation of PAI-1 and Fg with diabetic nephropathy

作　　者：黎镇赐[1] 罗义[1] 吕婧[1] 杨阳[1] 

机构地区：[1]广州市第一人民医院心内科,广东广州510180

出　　处：《中国医药科学》2012年第15期20-21,74,共3页China Medicine And Pharmacy

摘　　要：目的探讨2型糖尿病患者血浆中纤溶酶原激活物抑制物-1和纤维蛋白原活性水平变化及其与糖尿病肾病的相关性。方法对168例心内科的2型糖尿病患者及52例健康体检者检查血糖、空腹胰岛素、血脂、尿酸、血常规、凝血功能、PAI-1、Fg,测量血压、腰围、身高和体重并计算体重指数;根据尿蛋白排泄率分为正常对照组52例,2型糖尿病无DN组48例、DN微量白蛋白尿组66例、DN临床蛋白尿组54例;分析PAI-1、Fg与糖尿病肾病的相关性。结果与正常对照组相比,2型糖尿病组患者PAI-1、Fg水平明显升高,差异有统计学意义(P<0.05),且PAI-1、Fg水平随着UAER的增高而递增。多元回归分析显示,2型糖尿病患者的血浆PAI-1、Fg水平与UAER独立相关,提示体内PAI-1、Fg水平的高低与糖尿病肾病密切相关。结论 2型糖尿病患者炎症标志物PAI-1、Fg水平增高,PAI-1、Fg水平与糖尿病肾病密切相关,提示PAI-1、Fg水平升高可能是2型糖尿病合并微血管病变的危险因素。Objective To research the correlation of plasminogen activator inhibitor-1 and fibrinogen with diabetic nephropathy.Methods 220 cases were selected which included 168 in-patients with T2DM from cardiology department and 52 healthy residents.Systolic blood pressure,diastolic pressure,waist circumference,body mass index were tested based on weight and height.Plasma lipids,fasting blood glucose,fasting insulin,uric acid,and the blood levels of Fg and PAI-1 were also measured separately.The plasmic levels of PAI-1 and Fg in diabetic patients with or without diabetic nephropathy and normal controls were tested.Correlation of PAI-1 and Fg levels in T2DM patients with DN was analyzed.Results The blood levels of PAI-1 and Fg in patients with T2DM were higher than those health residents（P 〈 0.05）,and those were elevated in accordance with UAER.The stepwise regression analysis showed that the blood levels of PAI-1 and Fg were independently associated with UAER.Conclusion Diabetic nephropathy may be correlated with the high levels of PAI-1 and Fg,which may be risk factors of T2DM with microangiopathic.

关 键 词：纤溶酶原激活物抑制物-1 纤维蛋白原 2型糖尿病 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]