Zn-DDC羟丙基β环糊精包合物的制备与鉴定  

Preparation and characterization of zinc diethyldithiocarbmate HPβCD inclusion complexes

作　　者：刘侠[1] 王思玲[2] 

机构地区：[1]海南医学院药学院 海南省热带药用植物研究开发重点实验室,海南海口571101 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国医药科学》2012年第15期102-103,共2页China Medicine And Pharmacy

摘　　要：目的制备Zn-DDC羟丙基β环糊精包合物并进行鉴定。方法分别以研磨法、搅拌法、超声波法制备,用热分析法、粉末X-射线衍射法、红外光谱法鉴定。结果鉴定显示Zn-DDC羟丙基β环糊精包合物已形成,包合物的稳定常数为3451.57L/mol,且以溶液搅拌法制备更合适。结论羟丙基β环糊精可以显著增加Zn-DDC的溶解度。Objective To prepare and characterize zinc diethyldithiocarbmate HPβCD inclusion complexes.Methods Zn-DDC-HPβCD inclusion complexes was prepared by milling method,agitating method and ultrasound method separately and identified by DSC,X-ray and IR method respectively.Results The inclusion complexes were abtained.the stable constant of Zn-DDC-HPβCD was 3 451.57 L/mol.Conclusion The solubility of Zn-DDC was increased greatly by HPβCD.

关 键 词：Zn-DDC 羟丙基β环糊精 包合物 鉴定 

分 类 号：R943.4[医药卫生—药剂学] R927.2[医药卫生—药学]