内蒙古自治区2630名健康中小学生血清肌酐水平调查  

Creatinine concentration of 2630 healthy students in primary and middle schools in Inner Mongolia

作　　者：程歆琦[1] 邱玲[1] 丁海涛 吴卫[1] 国秀芝[1] 吴洁[1] 刘军挺[3] 韩少梅[5] 徐成丽[4] 朱广瑾[4] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院检验科,100730 [2]内蒙古医院检验科 [3]首都儿科研究所慢性病防治中心 [4]中国医学科学院基础医学研究所生理学教研室 [5]中国医学科学院基础医学研究所统计学教研室

出　　处：《中华检验医学杂志》2012年第9期805-809,共5页Chinese Journal of Laboratory Medicine

基　　金：科技部科技基础性工作专项项目资助课题（2006FY110300）

摘　　要：目的调查分析内蒙古自治区健康中小学生血清肌酐（Cr）水平，探讨不同民族、地区、性别和年龄的健康中小学生Cr水平的差异，并建立不同性别和不同年龄中小学生血清Cr的参考范围。方法本研究为大样本临床流行病学调查。采用分层、随机整群抽样的原则，于2009年7月-2010年6月，从内蒙古自治区的呼和浩特市、乌兰察布市、锡林郭勒盟和巴彦卓尔市随机抽取2630名9～18岁健康中小学生进行体检，并接受血清Cr检测。筛除离群数据个体后，共2614名受试者入选，男1288名，女1326名，其中汉族1584名，蒙古族1030名。采集受试者清晨空腹静脉血并分离血清，测定血清Cr水平。采用方差分析及t检验比较不同地区、民族、性别和年龄组间Cr水平的差异，SNK法进行组间的两两比较。采用百分位数描述不同生长发育阶段Cr水平的变化，并建立不同性别、不同年龄中小学生血清Cr的参考范围（P2.5～P97.5）。采用年龄别百分位数（LMS）曲线平滑法对曲线进行平滑。结果不同地区、不同民族、不同性别和不同年龄组间Cr水平的差异具有统计学意义。根据方差分析结果，分性别建立参考范围，其中男性9～11岁、12岁、13—14岁、15岁和16—18岁参考范围分别是35～66、37～73、39～78、47—87、49—91μmol／L；女性9～10岁、11～12岁、13—15岁和16～18岁参考范围分别是32～60、34—63、38—73和40～74μmol／L。结论初步建立了内蒙古自治区健康中小学生血清Cr的参考范围，对临床医生特别是儿科医生判断和评估9～18岁年龄段患者的肾功能有很好的参考价值。Objective To analyze the serum creatinine level among apparently healthy primary and secondary school students in Inner Mongolia and explore the distribution of serum creatinine by ethnic, regional, gender and age, and establish the reference interval of serum creatinine in different gender and different age groups of primary and secondary school students. Methods Large sample clinical epidemiological investigation was applied by two-stage clustering sampling method. Random sample of 2630 primary and secondary school students from 9 to 18-year-old was selected from four district in Inner Mongolia including Hohhot, Wulanchabu, Xilin Gol and Bayan Drow from July 2009 to June 2010. After screening outlier individual, the total of 2614 subjects were enrolled, involving 1288 male and 1326 female subjects, 1584 Han and 1030 Mongolian. The venous blood was collected and serum was separated. The serum creatinine concentration was measured as soon as possible. Furthermore, creatinine levels of different regions, ethnic, gender and age group were compared by analysis of variance or t-test and that of different group were compared by SNK method. Percentile was used to describe the distribution of serum Cr level of different age groups. The reference interval of serum Cr for primary and secondary school students were established by gender and age （ P2.5 - P97.5 ）- The curve was smoothed using age-specific percentile （LMS） curve smoothing method. Results The differences of Cr levels were statistically significant between different regions, ethnic, gender and age groups. The reference intervals of creatinine for 9 - 11, 12, 13 - 14, 15, and 16 - 18 year-old males were 35 - 66, 37 - 73, 39 - 78, 47 - 87 and 49 - 91 μmol/L, respectively. The intervals for 9 - 10, 11 - 12, 13 - 15, and 16 - 18 year-old females were 32 - 60, 34 - 63, 38 - 73 and 40 -74 μmol/L, respectively. Conclusion The reference intervals of serum creatinine for health primary and secondary school students in the Inner Mongolia is established, which i

关 键 词：肌酸酐 学生 参考值 

分 类 号：R446.1[医药卫生—诊断学]