基于list-mode数据的PET断层重建原理与实现  

Principle and Implementation of list-mode Image Reconstruction in PET

作　　者：张斌[1] 单保慈[2] 贠明凯[2] 赵书俊[1] 

机构地区：[1]郑州大学物理工程学院,郑州450001 [2]中国科学院高能物理研究所,北京100049

出　　处：《生物医学工程学杂志》2012年第5期814-819,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(81171410/H1809)

摘　　要：正电子发射断层扫描仪(PET)已经成为临床医学及诸多科学研究领域的基础性支撑装备,是当前科学研究的一个热点,而图像断层重建算法是其关键组成部分之一。目前大部分设备采用基于正弦图(sinograms)的统计迭代算法,而基于list-mode数据的重建算法具有许多独特优势,近年来受到研究者高度关注,正处于快速发展和完善过程中。本文以Eplus-166小动物PET为实验平台,采用S-LMEM重建算法和正交距离射线追踪方法,实现基于list-mode数据的断层重建,结果表明图像分辨率和对比度恢复达到设备固有性能指标,同时证明基于on-the-fly模式进行实时系统矩阵计算,实现动态重建是可行有效的。Positron emission tomography （PET） has become basic support equipment in clinical and many other scien- tific research fields and has been a hot research field at present. Tomography reconstruction algorithm is a key com- ponent of PET, and most PETs use statistical iterative reconstruction algorithms from sinograms data currently. However, tomography reconstruction from list-mode data possesses many unique advantages, and it has caused great attention and is in the process of rapid development and improvementin recently. We eventually achieved list-mode tomography reconstruction in this paper, using experimental data of small animal PET scanner Eplus-166, exploiting S-LMEM algorithm and orthogonal distance-based ray-tracer. The results demonstrated that image resolution and contrast recovery achieved inherent properties of the scanner and on-the-fly ray-tracing methods is feasible for dynam- ic reconstruction.

关 键 词：正电子发射断层成像 表模式 射线追踪 系统响应矩阵 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术]