补益肺肾、祛风化痰法防治哮喘复发的临床研究  

Clinical Study on Preventive Treatment of Tonifying Lung and Kidney,Eliminating Wind and Resolving Phlegm for Recurrence of Asthma

作　　者：王志英[1] 周学平[1] 李国春[1] 徐立然[2] 许立[1] 郭立中[1] 金路[1] 杨继兵[1] 蔡敏[3] 朱佳[4] 

机构地区：[1]南京中医药大学第一临床医学院,江苏南京210046 [2]河南中医学院一附院,河南郑州136300 [3]昆山市中医院呼吸科,江苏昆山215300 [4]南京中医药大学附属江苏省中西医结合医院,江苏南京210028

出　　处：《南京中医药大学学报》2012年第5期421-424,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金："十一五"国家科技支撑计划(2007BAI10B02-03)

摘　　要：目的观察根据补益肺肾、祛风化痰法研制的温养化痰方、清养化痰方防治支气管哮喘复发的临床疗效。方法采用多中心、队列研究方案,将符合纳入病例标准的支气管哮喘缓解期患者121例(名中医组队列)根据寒哮、热哮的不同,分别给予温养化痰方和清养化痰方,并与常规中医治疗的81例(常规组队列)对照,分别给予固本咳喘汤和麦味地黄汤,观察名中医队列在缓解哮喘的症状体征,控制病情,减少复发或减轻发作程度等方面的疗效。结果寒哮、热哮的名中医组及名中医合计组分别与常规治疗组比较,临床控制显效率有显著性差异(P<0.01);各组治疗后ACT评分均有提高,治疗前后的差值名中医组均大于常规组,且差别显著(P<0.01)。治疗后肺功能指标均有改善,治疗前后的差值各证型名中医组与常规组比较,有显著性差别(P<0.05,P<0.01)。结论名中医方虚实兼顾的治疗方案治疗支气管哮喘慢性持续期(肺肾气虚、寒痰内伏证,肺肾阴虚、痰热内蕴证)患者具有良好的抗复发疗效,优于单纯以补益为法的常规中医组。OBJECTIVE To study clinical curative effect of preventive treatment for recurrence of bronchial asthma by the prescriptions of Wenyang Huatan Fang （WYHTF） and Qingyang Huatan Fang （QYHTF） based on thetreatment principle of tonifying lung and kidney, eliminating wind and resolving phlegm. METHODS By adopting the programme of multi-center and cohort study, we gave WYHTF and QYHTF respecitvely to cold asthma cases and heat asthma cases of 121 patients （Co- hort of Renowned TCM Doctor Group, Cohort I） who have bronchial common treatments by taking Guben Kechuan Decoction （GBKCD） and Maiwei Dihuang Decoction （MWDHD） respectively to observe the curative effect of Cohort I on relieving asth- maic symptoms and signs, controlling disease and reducing recurrence. RESULTS In comparison of cold asthma and heat asthma between cohorts and between Cohort I and Cohort II, the efficiency rate of clinical control showed significant difference （P〈0.01）. After treatment, ACT score of each group improved, while the differentials between prior-treatment and posttreatment in Cohort I were more obvious than Cohort II with significant difference （P〈0.01）. Also, indices of pulmonary function were all improved after treatment, and compared the differentials between prior-treatment and post-treatment of each syndrome in Cohort I and that of Cohort II, there were significant differences （P〈0.05, P〈0.01）. CONCLUSION The re- nowned TCM doctors treatment, with a good effect on anti-recurrence, considering both deficiency and excess for remission stage of bronchial asthma （including qi deficiency of lung and kidney, interiorly hidden cold phlegm, yin deficiency of lung and kidney, interior accumulation of phlegm heat）, is better than common TCM treatment by merely tonifying function.

关 键 词：支气管哮喘 补益肺肾 祛风化痰法 防治复发 队列研究 

分 类 号：R242[医药卫生—中医临床基础]