代谢综合征患者血清Apelin水平与血糖的关系  

Relationship between Serum Apelin Level and Plasma Glucose in Patients with Metabolic Syndrome

作　　者：孙桂丽[1,2] 黎英荣[3] 夏宁[3] 

机构地区：[1]广西医科大学第三附属医院 [2]南宁市第二人民医院内分泌科,南宁市530031 [3]广西医科大学第一附属医院代谢糖尿病中心,南宁市530021

出　　处：《广西医学》2012年第11期1450-1452,共3页Guangxi Medical Journal

基　　金：广西医药卫生科研课题(桂卫Z2007080)

摘　　要：目的探讨代谢综合征(MS)患者血清Apelin水平与血糖的关系。方法 MS 69例和糖调节正常者63例;前者包括2型糖尿病(MSⅠ组)35例和糖调节受损(MSⅡ组)34例,后者包括超重/肥胖33例(超重/肥胖组)和健康对照30例(健康对照组)。采用酶联免疫吸附法测定各组血清Apelin含量及空腹血糖、胰岛素水平,以稳态模型评价胰岛素抵抗指数(HOMA-IR)。结果 MSⅠ组血清Apelin水平明显高于MSⅡ组及超重/肥胖组[(475.8±37.3)ng/L vs(451.5±54.7)ng/L vs(430.3±52.1)ng/L](P<0.01),且均高于健康对照组。结论糖尿病/糖调节受损可以引起血清Apelin水平升高,其可能是由于胰岛素抵抗加重所致。Objective To investigate the relationship between serum apelin level and plasma glucose in patients with metabolic syndrome （MS）. Methods Sixty nine MS patients including 35 cases of type 2 diabetes mellitus （ MS Ⅰ group） and 34 cases of impaired glucose regulation （ MS Ⅱ group）, and 63 cases of normal glucose regulation including 33 cases of overweight or obesity（ overweight/obesity group） and 30 healthy controls（NC group） were enrolled in the study. ELISA assay was used to detect serum apelin levels in four groups. Fasting plasma glucose （FPG） and insulin were determined, and the steady-state model was applied to evaluate HOMA insulin resistance （HOMA-IR）. Results The serum apelin level of MS Ⅱ group[ （475.8 ±37.3）ng/L] was higher than that of MS Ⅱgroup[ （451.5±54.7）ng/L], and overweight/obesity group significantly[ （430.3±52.1 ）ng/L,P 〈0.01 ] ;The serum apelin level of each group above was higher than that of NC group significantly. Conclusion Diabetes/impaired glucose regulation leads to the increase of serum apelin level,which might be caused by the increased insulin resistance.

关 键 词：APELIN 代谢综合征 2型糖尿病 肥胖 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]