焦炉工人相关基因多态性与遗传损伤的关系研究  

Research on the Relationship of Gene Polymorphism and Genetic Damage in Coke Oven Workers

作　　者：胡志鹏[1] 郑金平[2] 

机构地区：[1]长治市妇幼保健院,山西长治046011 [2]山西医科大学公共卫生学院毒理教研室,太原030001

出　　处：《医学综述》2012年第18期2940-2944,共5页Medical Recapitulate

基　　金：国家自然科学基金(30872137);山西省自然科学基金(2009011049-1);山西医科大学科技创新基金(01200701)

摘　　要：焦炉作业环境可导致焦炉工人的细胞遗传物质损伤,是肿瘤发生的主要机制之一。近年来研究发现,个体某些遗传基因的多态性可影响焦炉工人的遗传损伤程度,在焦炉逸散物诱发疾病的发生、发展中发挥重要作用。现就近年来对焦炉工人遗传损伤有关的基因多态性的研究作一综述,为焦炉职业接触者筛选易患个体或高危人群,并对易患人群实施有效的个体防护提供依据。The occupational exposure of coke oven workers could lead to cytogenetic damage,which is one of the major mechanisms of tumor. Recent studies have found that certain gene polymorphisms of individuals could affect the degree of genetic damage, and plays an important role in the development of disease induced by coke oven emissions. Here is to make a review on the recent studies of gene polymorphisms on cytogenetic damage to provide a basis of health protection for susceptible individuals and screening of high risk of occupational exposure workers.

关 键 词：焦炉工人 遗传损伤 基因多态性 

分 类 号：R114[医药卫生—卫生毒理学]