纤维细胞与支气管哮喘呼吸道重构  

Fibrocyte and Airway Remodeling in Asthma

作　　者：刘海燕[1] 王彤[1] 

机构地区：[1]南京医科大学第一附属医院呼吸内科,南京210029

出　　处：《医学综述》2012年第18期2970-2972,共3页Medical Recapitulate

摘　　要：来源于骨髓间叶祖细胞的人类纤维细胞可以表达许多表面分子,这些表面分子与白细胞、造血干细胞以及成纤维细胞表型有关。纤维细胞能从血液循环到达外周组织,并且根据外周组织生态位,组织纤维细胞可以分化、增殖成各种间叶细胞。这些外周组织生态位是非常重要的,它可以使纤维细胞发挥组织修复作用,这些生态位可能与慢性呼吸道疾病(如哮喘)有关,纤维细胞可以通过调节多种致呼吸道重构因子,如炎性介质、细胞因子和趋化因子等的生成和活化,最终导致呼吸道重构。Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers relatedto leukocytes,hematopoietic stem cells and a diverse set of fibroblast phenotypes.Fibrocytes can be recruited from the circulation to the tissue where they can further differentiate and proliferate into various mesenchymal cell types depending on the tissue niche.The local tissue niche is important because it modulates the fibrocytes and coordinates their role in tissue repair.However,plasticity of a niche may be co-opted in chronic airway diseases such as asthma.Fibrocytes may through regulating the generation and activation of various airway remodeling factors,such as inflammatory mediators,cytokines and chemokines,eventually lead to airway remodeling.

关 键 词：纤维细胞 哮喘 呼吸道重构 

分 类 号：R56[医药卫生—呼吸系统]