a-β_2GP1、ACA在早期先兆流产患者妊娠丢失中的临床意义  

Clinical Significance of a-β_2GP1, ACA in Pregnancy Loss in Patients with Threaten Abortion in the First Trimester

作　　者：黄神姣[1] 陈敦金[1] 罗太珍[1] 谭鹰[1] 

机构地区：[1]广州医学院第三附属医院妇产科,广东广州510150

出　　处：《临床医学工程》2012年第10期1684-1685,共2页Clinical Medicine & Engineering

基　　金：广东省医学科研基金(A2010268)

摘　　要：目的评价a-β2GP1、ACA在早期先兆流产患者妊娠丢失中的临床意义。方法采用前瞻性病例对照研究,对80例8～12周先兆流产患者(研究组)和35例正常孕妇(对照组)的血清a-β2GP1、ACA进行检测,并随访至妊娠结束。研究组根据妊娠结局分为足月分娩组以及妊娠丢失组。结果 80例先兆流产患者中,早期妊娠丢失者46例(57.5%),足月分娩者34例(42.5%)。早期流产者平均孕周为(10.5±1.2)周。a-β2GP1IgM型阳性率在妊娠丢失组(41.3%)较其他两组(14.7%,0%)更多见,差异有显著性意义(P<0.05)。IgG型各组间无明显差异。妊娠丢失组ACAIgM、IgG型阳性率较其它两组高,但差异无显著性差异。结论 a-β2GP1IgM会增加早期先兆流产患者妊娠丢失的风险。Objective To evalue the clinical significance of a-β2GP1, ACA in pregnancy loss in women with threaten abortion in the first trimester. Methods Anti-β2-glycoprotein I, anticardiolipin antibody was tested in 80 patients with threaten abortion in the first trimester （study group）, and 35 healthy pregnant without complicated gestation （control group） and the pregnant outcome was followed up. Study group was divided into pregnancy loss and delivery at term group according to the pregnant outcome. Results Of the 80 patients with threatened abortion, 46 （57.5%） progressed early pregnancy loss and 34 （42.5%） experienced to deliver at term. Among the antibodies evaluated, only anti-β2-glycoprotein 1 IgM isotype was significantly more frequent in those women whose pregnancy resulted in spontaneous abortion （41.3%） than in the other both groups （14.7%, 0%, P 〈0.05）. The positive rates of ACA IgM, IgG were higher in pregnancy loss group than the other goups, but without statistic significance （P 〉0.05）. Conclusions A-β2GP1 IgM is associated with an increased risk of pregnancy loss in women with threatened abortion in the first trimester.

关 键 词：a-β2GP1 ACA 先兆流产 妊娠丢失 

分 类 号：R714.21[医药卫生—妇产科学]