降钙素原在诊断早产儿医院感染败血症的临床意义  

Clinical Significance of Procalcitonin Test in the Diagnosis of Hospital-Acquired Sepsis in Preterm Infants

作　　者：钱苗[1] 辜楠[1] 韩树萍[1] 

机构地区：[1]南京医科大学附属南京妇幼保健院儿科,江苏南京210004

出　　处：《临床医学工程》2012年第10期1689-1690,共2页Clinical Medicine & Engineering

基　　金：江苏省医学重点人才基金项目资助(RC2011021)

摘　　要：目的探讨降钙素原在诊断早产儿医院感染败血症的临床意义。方法选择我院分娩的我院分娩的早产儿(胎龄<37周)64例,其中医院感染败血症组早产儿32例,无败血症对照组早产儿32例,入院后使用抗生素前抽取静脉血检测降钙素原(PCT)与C反应蛋白(CRP),对CRP与PCT诊断早产儿医院感染败血症进行诊断性试验比较。结果与无败血症对照组早产儿相比,医院感染败血症组早产儿CRP和PCT的含量均明显升高(P<0.05),PCT诊断新生儿败血症的敏感性为93.3%、特异性为88.2%、阳性预测值和阴性预测值分别为87.5%、93.8%,诊断准确性为90.6%均较CRP高。结论 PCT对于早期诊断早产儿医院感染败血症具有较高的诊断准确性,具有一定的临床应用价值。Objective To study the clinical significance of procalcitonin test in the diagnosis of hospital-acquired sepsis in preterm infants. Methods 64 preterm infants （gestational age 〈 37 weeks） in our hospital were recruited in the study, including 32 preterm infants with hospital-acquired sepsis and 32 preterm infants without sepsis as control group. After hospital admission and previous use of antibiotics, the serum proealcitonin （PCT） and C reactive protein （CRP） was measured, CRP and PCT diagnosis of premature infants infected with septicemia in hospital. The diagnostic test of CRP and PCT for hospital-acquired sepsis was conducted. Results The levels of CRP and PCT of hospital-acquired sepsis in preterm infants were higher than those of control group （2~ 〈0.05）. PCT diagnosis of hospital-acquired sepsis in preterm infants with a sensitivity of 93.3%, specificity of 88.2%, positive and negative predictive values were 87.5%, 93.8%, the diagnostic accuracy of 90.6% were higher than those in CRP. Conclusions For early diagnosis of hospital-acquired sepsis in preterm infants, procalcitonin has a high diagnostic accuracy and certain value in clinical application.

关 键 词：早产儿 降钙素原 医院感染 败血症 

分 类 号：R722.131[医药卫生—儿科]