6种手性化合物在自制的直链淀粉-三[(s)-α-甲基苄基氨基甲酸酯]手性固定相上的直接拆分  

Enantioseparation of 6 racemates on amylose-tris[(s) -α-methylbenzylcarbamate] chiral stationary phase

作　　者：韩小茜[1] 祁媛[1] 安丽丽[1] 王兆霞[1] 张大兵[2] 黄思凯[1] 马淑娟[1] 

机构地区：[1]兰州交通大学化学与生物工程学院,兰州730070 [2]江苏汉邦科技有限公司,淮安223005

出　　处：《分析仪器》2012年第5期63-66,共4页Analytical Instrumentation

基　　金：江苏汉邦科技有限公司资助

摘　　要：本文在自制的涂敷型直链淀粉-三[(s)-α-甲基苄基氨基甲酸酯]手性固定相上对反-2,3-二苯基环氧乙烷、托葛尔碱、苯偶姻、喹禾灵、戊唑醇、禾草灵等6种手性化合物进行了手性拆分。同时在流速0.5mL/min,检测波长254nm条件下,系统考察了多种色谱模式(正相、反相和极性有机相)下流动相组成对6种化合物手性分离的影响。化合物2、3和6获基线分离,化合物1、4和5获部分分离。The enantioseparation of six chiral compounds （trans-stilbene oxide, troger-base, benzoin, quizalofop, tebuconazole, diclofop-methyl） on the coated amylose-tris[（s） -α-methyl- benzylcarbamate] chiral stationary phase, which was prepared in authors＇lab, was achieved. At the condition of flow rate is 0.5mL/min, λ is 254nm, the influence of multimodal elution with normal-phase or reversed-phase or the polar organic phase on the enantioseparation of six chiral compounds was investigated. Troger-base, benzoin and diclofop-methyl were achieved baseline separation; trans-stilbene oxide, quizalofop and tebueonazole were obtained partial separation.

关 键 词：直链淀粉-三(s)-α-甲基苄基氨基甲酸酯] 手性拆分 高效液相色谱 

分 类 号：O657.72[理学—分析化学]