白细胞介素-1β基因启动子-31位点单核苷酸多态性与甲型H1N1流感易感性的关联分析  

Association between-31 single nucleotide polymorphism in the promoter of interleukin-1β gene and susceptibility to A H1N1 influenza

作　　者：林巧[1] 张国良[2] 杨辉[2] 刘腊香[1] 刘映霞[2] 刘晋洪[1] 

机构地区：[1]深圳市宝安区慢性病防治院,广东深圳518133 [2]深圳市第三人民医院,广东深圳518112

出　　处：《临床肺科杂志》2012年第11期1941-1943,共3页Journal of Clinical Pulmonary Medicine

基　　金：深圳市科技计划项目(201002107)

摘　　要：目的探讨白细胞介素-1β(IL-1β)基因启动子-31位点单核苷酸多态性(SNP)与甲型H1N1流感易感性的关系。方法采用病例-对照研究方法,应用TaqMan探针技术,对167例H1N1流感患者和192例健康对照人群IL-1β基因-31位点进行等位基因分型,比较两组人群基因型分布及频率差异。结果 IL-1β基因-31位点具有T和C两种等位基因,其中H1N1流感组T、C等位基因频率分别为38.3%和61.7%,对照组T、C等位基因频率分别为54.4%和45.6%,两组差异具有统计学意义(P<0.001,OR=1.922,95%CI 1.426-2.590)。结论 IL-1β基因启动子-31多态性位点与甲型H1N1流感易感性相关,C等位基因是甲型H1N1流感易感基因。Objective To explore the association between -31 single nucleotide polymorphisms（SNP） in the promoter of IL-1β gene and susceptibility to A H1N1 influenza. Methods The study used TaqMan probe to type the allele of -31 SNP in IL-1β in the H1NI group（ n = 167 ） and the healthy control group （ n = 192）, and then compared the two groups＇ genotype distributions and frequency difference using case-control method. Results IL-1β gene -31 SNP involved T and C allele, with frequency 38.3% and 61.7% in the H1 N1 groups respectively, and 54.4% and 45.6% in the healthy control group. The difference between the two groups showed statistical significance （ P 〈 0. 001, OR = 1. 922,95 % CI 1. 426 -2. 590 ）. Conclusion IL-1β gene -31 SNP is associated with susceptibility to A H1N1 influenza,and C allele is the susceptible allele for A H1N1 influenza.

关 键 词：白细胞介素-1Β TAQMAN探针 甲型H1N1流感 单核苷酸多态性 

分 类 号：R511.7[医药卫生—内科学]