中医药治疗冠心病的文献质量评价  

Quality Evaluation of Literature on TCM Therapy for Coronary Heart Disease

作　　者：郭齐[1] 田昕[2] 杨傲然 吴丹[1] 王志国[4] 

机构地区：[1]江苏大学基础医学与医学技术学院 [2]北京中医药大学基础医学院 [3]北京市中西医结合医院 [4]中国中医科学院医学实验中心

出　　处：《中医杂志》2012年第20期1734-1736,共3页Journal of Traditional Chinese Medicine

基　　金：江苏大学高级专业人才科研启动基金项目(11JDGO74);江苏省大学生实践创新训练计划项目(1201270046)

摘　　要：目的对中医药治疗冠心病的文献进行质量评价,明确中医药治疗冠心病的疗效及存在的问题。方法检索中国生物医学文献光盘、中文生物医学期刊文献数据库、中医药科技文献数据库、维普中文科技期刊数据库、中国期刊全文数据库、万方数据库、中国医学学术会议论文数据库中1982年1月至2012年1月有关中医药治疗冠心病的临床研究文献,制定冠心病治疗性文献系统质量评价及信息采集表,对纳入文献的随机方法、分配隐匿、诊断标准、疗效评定标准、基线可比性、盲法、随访、病例失访、退出、脱落、统计方法等方面进行评价。结果符合纳入标准的文献共82篇。其中多中心研究8篇(9.7%);有明确诊断标准67篇(82.0%);采用部级、局级标准为纳入标准的37篇(45.1%),有明确疗效判定标准的73篇(89.0%);做组间均衡性比较64篇(78.0%);正确使用随机分配方法及实施盲法均为8篇(9.8%);82篇文献均未描述对受试对象的依从性检测;有随访和失访记录分别为5篇(6.1%)和2篇(2.4%);明确所用统计方法58篇(70.7%),但均无后验性统计分析;记录不良反应及安全性72篇(87.8%)。结论中医药治疗冠心病临床研究缺乏多中心研究,诊断和疗效评定标准交叉混用,组间均衡性、随机分配和随访、失访等有关研究方案质量的评价较低。Objective To observe the therapeutic effect of Chinese medicine combined with acupuncture for sudden deafness.Methods The sudden deafness patients were randomized into Chinese medication group and western medication group,with 100 in each.The modified Yingqiao Powder（Lonicera and Forsythia Powder）,Longdan Xiegan Decoction（Gentian Liver-Draining Decoction） and Tongqiao Huoxue Decoction（Orifice-Freeing Blood-Quickening Decoction） were given to the patients in the Chinese medication group respectively according to the three syndromes of invasion of the external pathogenic wind,upward flaring of liver fire,and qi stagnation with blood stasis.Then acupuncture was applied once every other day on Yifeng（TE 17）,Ermen（TE 21）,Tinggong（SI 19）,Tinghui（GB 2）,Waiguan（TE 5）,Hegu（LI 4）,Zusanli（ST 36）,Sanyinjiao（SP 6）,Taixi（KI 3）,Taichong（LR 3） and Zuqiaoyin（GB 44）.Xuesaitong Injection（injection for thrombosis） was injected intravenously as well.The western medication group was treated with alprostadil injection and mecobalamin.The improvement of hearing,tinnitus and vertigo,the time of symptom disappearance,the therapeutic and adverse reactions were observed in both groups.Results The total effective rate of hearing was 91.00% and 69.70% respectively in the Chinese medication group and western medication group,with significant difference between groups（P〈0.05）.The total effective rate of tinnitus was 94.85% and 90.11% respectively in the Chinese medication group and western medication group,with no significant difference between groups（P〉0.05）.The total effective rate of vertigo was 95.92% and 97.22% respectively in the Chinese medication group and western medication group,with no significant difference between groups（P〉0.05）.The difference between groups in symptom disappearance time of hearing,tinnitus and vertigo was not statistically significant（P〉0.05）.There were 22 and 32 cases of invasion of the external pathogenic wind syndrome in the Chi

关 键 词：冠心病 中医药疗法 文献质量评价 

分 类 号：R259[医药卫生—中西医结合]