竹叶黄酮对小鼠H22肿瘤抑制作用的研究  

Research on Tumor Inhibitory Effect of Bamboo Flavonoids on H22 Tumor Bearing Mice

作　　者：黄宇玫[1] 罗文艳[2] 

机构地区：[1]南昌大学科学技术学院,江西南昌330029 [2]南昌大学第四附属医院,江西南昌330003

出　　处：《实用中西医结合临床》2012年第5期1-3,共3页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨竹叶黄酮对荷瘤小鼠的抑瘤作用。方法:观察不同剂量竹叶黄酮对荷瘤小鼠肿瘤的抑瘤率、生命延长率、胸腺指数、脾脏指数以及用药前后体重变化等指标的影响。结果:竹叶黄酮具有一定的体内抗肿瘤作用,大、小剂量组的抑瘤率分别为31.6%、9.4%。竹叶黄酮组对荷瘤小鼠虽然没有环磷酰胺那么明显的抗肿瘤作用,但其毒副作用较少,还能延长腹水瘤小鼠的生存时间,增强小鼠免疫能力。结论:竹叶黄酮对小鼠恶性腹腔积液的形成具有抑制作用,还能抑制实体瘤的生长并增强小鼠机体的免疫能力,这为临床应用提供了实验依据。Objective：To investigate tumor inhibitory effect of bamboo flavonoids. Methods ： Hepatic cancer H22 model in mice was performed, observed the tumor inhibitory rate and life extension rate,index of thymus and spleen ,weight with different dosage of bamboo flavones .Results：Bamboo flavonoids had some anti-tumor effect in vivo, The tumor inhibition rate of the big and small dose group was 31.6%, 9.4% respectively.Compared with CTX, bamboo flavonoids have less obvious anti-tumor effect ,but fewer side effects, also can extend survival time of tumor-bearing mice in ascites, enhance immunity in mice.Conclusion：Bamboo flavonoids on routine malignant peritoneal effusion formation is inhibited, and enhancement of murine immune capacity, which can provide the experimental basis for clinical application.

关 键 词：H22 竹叶黄酮 生命延长率 抑瘤率 脏器指数 

分 类 号：R285.5[医药卫生—中药学]