正交试验优选丹参饮口服液的水提取工艺研究  

Study on water extraction process of Danshen Decoction Oral Liquid

作　　者：蒲清荣[1] 陈玉兰[1] 黄锐[1] 赵剑[1] 颜章龙[1] 唐定宏[1] 

机构地区：[1]泸州医学院附属中医医院,四川泸州646000

出　　处：《药物评价研究》2012年第4期270-272,共3页Drug Evaluation Research

基　　金：泸州市科技局课题(LSCQ<2010>41号)

摘　　要：目的探索丹参饮口服液的最佳水提工艺。方法以水提物中有效成分丹参素钠为指标,采用高效液相色谱法测定丹参素钠含量,运用正交设计法对丹参饮口服液水提取工艺进行优选。结果丹参饮口服液最佳水提取工艺为按5倍量处方比例称取粗碎药材,浸泡0.5 h,加入10倍量水煎煮3次,每次1.5 h。结论采用该水提工艺提取,水提取物中丹参素钠的收率较高且稳定。Objective To optimize the water extracting process for Selection of Danshen Decoction Oral Liquid.Methods Taking sodium Danshensu as an indicator,HPLC was used to detect the content of sodium Danshensu and orthogonal design to optimize the water extraction process of Danshen Decoction Oral Liquid.Results The optimal extraction process of Danshen Decoction Oral Liquid as follow： The crushed crude traditional Chinese medicinal materials were weighed in a five-fold volume ratio of prescription with soaking for 0.5 h,decocting for three times by ten-fold water,once for 1.5 h.Conclusion Using the water extract process,the yield in the water extract of sodium Danshensu is high and stable.

关 键 词：丹参饮口服液 水提取工艺 正交设计 丹参素钠 高效液相色谱法 

分 类 号：R943[医药卫生—药剂学]