锦灯笼根和茎化学成分研究  

Chemical constituents in roots and stems of Physalis alkekengi var. franchetii

作　　者：李兆春[1] 陈重[1] 李笑然[1] 许琼明[1] 杨世林[1] 

机构地区：[1]苏州大学药学院,江苏苏州215123

出　　处：《中草药》2012年第10期1910-1912,共3页Chinese Traditional and Herbal Drugs

摘　　要：目的研究锦灯笼Physalis alkekengi var.franchetii根和茎的化学成分。方法利用硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法、中压柱色谱及半制备高效液相色谱等方法分离纯化,通过核磁共振谱、质谱等光谱数据鉴定化合物结构。结果分离得到10个化合物,分别鉴定为β-谷甾醇(1)、胡萝卜苷(2)、木犀草素(3)、木犀草素-7-O-β-D-葡萄糖苷(4)、异岩藻甾醇(5)、硬脂酸单甘油酯(6)、睡茄内酯A(7)、胡萝卜苷-6′-O-硬脂酸酯(8)、齐墩果酸(9)、(Z)-9,10,11-三羟基-12-十八碳烯酸(10)。结论化合物6、8、10为首次从该属植物中分离得到,化合物5、7、9为首次从该植物中分离得到。Objective To investigate the chemical constituents in the roots and stems of Physalis alkekengi var.franchetii.Methods The constituents were isolated by chromatography on silica,Sephadex LH-20 gel columns,medium pressure and semi-preparative HPLC and their structures were elucidated by chemical properties and spectroscopic analyses.Results Ten compounds were isolated and their structures were identified as β-sitosterol（1）,daucosterol（2）,luteolin（3）,luteolin-7-O-β-D-glucoside（4）,isofucosterol（5）,glyceryl monostearate（6）,withanolide A（7）,daucosterol-6′-O-stearate（8）,oleanolic acid（9）,and（Z）-9,10,11-trihydroxy12-octadecenoic acid（10）.Conclusion Compounds 6,8,and 10 are obtained from the plants in this genus for the first time.Compounds 5,7,and 9 are obtained from this plant for the first time.

关 键 词：锦灯笼 异岩藻甾醇 睡茄内酯A 胡萝卜苷-6′-O-硬脂酸酯 (Z)-9 10 11-三羟基-12-十八碳烯酸 

分 类 号：R284.1[医药卫生—中药学]