复方小儿湿疹微乳的制备及经皮渗透研究  

Preparation and transdermal delivery of compound infantile eczema microemulsion

作　　者：涂瑶生[1,2] 李绍林[1,2] 孙冬梅[1,2] 张建军[2] 

机构地区：[1]广州中医药大学,广东广州510405 [2]广东省中医研究所,广东广州510095

出　　处：《中草药》2012年第10期1939-1945,共7页Chinese Traditional and Herbal Drugs

摘　　要：目的以中药复方小儿湿疹方有效部位为模型药物,制备治疗小儿湿疹的经皮给药复方微乳。方法通过单因素试验及伪三元相图的绘制筛选微乳组分,并以药物体外经皮渗透速率进一步优化微乳处方。结果优选的复方小儿湿疹微乳处方为肉豆蔻酸异丙酯-Cremophor EL-丙三醇-水(6.5∶29.25∶29.25∶35),平均粒径为(24.54±0.22)nm,Zeta电位为(26.5±0.2)mV;黄连生物碱、丹皮酚稳态透皮速率(Js)分别为114.70、74.09μg/(cm2.h),比原湿疹洗剂的Js分别提高了17和10倍。结论复方小儿湿疹微乳性状均一、澄清透明,质量稳定,透皮性能好。Objective Taking the effective part of infantile eczema formula as model drug to prepare transdermal delivery compound microemulsion used for the treatment of infantile eczema.Methods Microemulsion formula was optimized by using single factor test and drawing pseudo-ternary phase diagram.The formula was further optimized with in vitro permeation rate of drug.Results The optimized formula of microemulsion was isopropyl myristate-cremophor EL-glycerol-water（6.5∶ 29.25∶ 29.25∶ 35）.The mean diameter was（24.54 ± 0.22） nm,and Zeta potential is（26.5 ± 0.2） mV.The steady penetration rates（Js） of total alkaloids in Coptidis Rhizoma and paeonol were 114.70 and 74.09 μg/（cm2.h）,which were respective 17 and 10 times more than those of former eczema lotions.Conclusion Compound infantile eczema microemulsion is homogeneous,clear,translucent,stable,and highly infiltrative.

关 键 词：复方小儿湿疹微乳 黄连总生物碱 丹皮酚 复方微乳 伪三元相图 体外经皮渗透 

分 类 号：R283.6[医药卫生—中药学]