Synthesis and Properties of 1,3-bis-adamantyl Disubstituted Ureas and Biureas  

作　　者：Gennadiy Butov Vladimir Burmistrov Saad Karim Ramez 

机构地区：[1]Branch of Chemistry, Chemical Technology of Volzhsky Politechnical Institute (branch), Volgograd State Technical University,Volgograd 404121, Russia

出　　处：《Journal of Chemistry and Chemical Engineering》2012年第9期774-777,共4页化学与化工（英文版）

摘　　要：1,3-disubstituted ureas of adamantine series are potent for hypertension and inflammatory treatment. The most valuable parameters of these compounds are melting point and solubility. Higher melting point leads to lower bioavailability and for most of the compounds investigated before it was very high. Usage of isocyanates containing 1,3-dimethyladamantane fragment will significantly decrease the melting point, improve solubility and therefore improve bioavailability of 1,3-disubstituted ureas and other biologically active compounds produced on its base. This article presents new 1,3-disubstituted ureas and biureas synthesized by the authors.

关 键 词：ISOCYANATE ADAMANTANE adamantyl UREA 1 3-dimethyladamantane. 

分 类 号：TQ421.12[化学工程] TQ221