Lipofuscin-and Melanin-related Fundus Autofluorescence in Patients with Submacular Idiopathic Choroidal Neovascularization  

作　　者：Xijia Peng Wenfang Zhang 

机构地区：[1]Department of Ophthalmology, Rehabilitation Center Hospital of Gansu, Lanzhou 730000, China [2]Department of Ophthalmology, the Second Hospital of Lanzhou University, Lanzhou 730030, China

出　　处：《Eye Science》2012年第3期138-142,共5页眼科学报（英文版）

基　　金：supported by a grant from the Science and Technology Support Project of Gansu Province(No.090NKCA093)

摘　　要：Purpose:.To compare melanin-related near-infrared fundus autofluorescence (NIA; excitation 787 nm, emission> 800 nm) with lipofuscin-related fundus autofluorescence (FAF; excitation 488 nm, emission > 500 nm) in patients with idiopathic choroidal neovascularization (ICNV). Methods: FAF, NIA, fundus fluorescein angiography (FFA) and indocyanine green angiography.(ICGA).were obtained using a confocal scanning laser Ophthalmoscope HRA2 (Heidelberg Retina Angiograph 2).in 18 eyes of 18 patients with ICNV. Results:.Eighteen eyes had classic CNV, and autofluorescence imaging showed hypoautofluorescence at the site of CNV..A well-defined hyperautofluorescent ring was detected surrounding the CNV in all 18 eyes with NIA imaging. In our sample,.the FAF patterns around the CNV were classified as normal (n=1,.5.56%), well-defined hyperautofluorescent ring (n=7,.38.89%), or ill-defined hyperautofluorescent ring (n=10, 55.56%). Conclusion:.The patterns of FAF and NIA indicated different involvement of lipofuscin and melanin in the pathophysiological process of ICNV. Compared to FAF imaging, NIA imaging appears to be a superior noninvasive method for in vivo visualization of retinal pigment epithelium (RPE) abnormalities in ICNV patients.To compare melaninrelated nearinfrared fundus autofluorescence （NIA; excitation 787 nm, emission〉 800 nm） with lipofuscinrelated fundus autofluorescence （FAF; excita tion 488 nm, emission 〉 500 nm） in patients with idiopathic choroidal neovascularization （ICNV）. Methods： FAF, NIA, fundus fluorescein angiography （FFA） and indocyanine green angiography （ICGA） were obtained us ing a confocal scanning laser Ophthalmoscope HRA2 （Hei delberg Retina Angiograph 2） in 18 eyes of 18 patients with ICNV. Results： Eighteen eyes had classic CNV, and autofluores cence imaging showed hypoautofluorescence at the site of CNV. A welldefined hyperautofluorescent ring was detected surrounding the CNV in all 18 eyes with NIA imaging. In our sample, the FAF patterns around the CNV were classified as normal （n=l, 5.56%）, welldefined hyperautofluorescent ring （n=7, 38.89% ）, or illdefined hyperautofluorescent ring （n= 10, 55.56%）. Conclusion： The patterns of FAF and NIA indicated different involvement of lipofuscin and melanin in the pathophysiologi cal process of ICNV. Compared. to FAF imaging, NIA imag ing appears to be a superior noninvasive method for in vivo visualization of retinal pigment epithelium （RPE） abnormali ties in ICNV patients. （Eye Science 2012; 27：138 142）

关 键 词：自体荧光 新生血管 黑色素 脉络膜 脂褐素 眼底 患者 黄斑 

分 类 号：Q78[生物学—分子生物学] O43[机械工程—光学工程]