不稳定型心绞痛患者C-反应蛋白基因多态性与其血清水平的相关性  

The correlation of CRP gene polymorphism and its serum level in patients with unstable angina pectoris

作　　者：杨海涛[1] 何国平[1] 戚传平[2] 许联红[2] 钱亿超[1] 

机构地区：[1]江苏大学附属武进医院心血管内科,江苏常州213002 [2]江苏大学附属武进医院中心实验室,江苏常州213002

出　　处：《南京医科大学学报（自然科学版）》2012年第9期1246-1249,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：常州市科技计划项目[常科发(2009)90号]

摘　　要：目的:探讨中国苏南地区汉族人群不稳定型心绞痛(unstable angina pectoris,UAP)患者C-反应蛋白(C-reactive protein,CRP)基因+1444C/T多态性与其血清CRP水平的相关性。方法:本研究包括172例不稳定型心绞痛患者(UAP组)和230例非冠心病者(对照组),分别应用酶联免疫吸附法和聚合酶链反应-限制性片段长度多态性法检测血清CRP水平及CRP基因+1444C/T多态性。结果:①本研究人群存在CRP基因+1444C/T多态性;②UAP患者血清CRP水平(8.269/9.179μg/ml)显著高于非冠心病者(3.578/2.236μg/ml)(P<0.001),且经多因素Logistic回归校正各影响因素后,仍提示血清CRP水平与UAP发病风险相关;③血清CRP水平在UAP组与对照组各基因型之间无显著差异(P>0.05),进一步按性别和年龄分组后,仍未发现该基因多态性不同基因型间的血清CRP水平有任何差异(P>0.05)。结论:中国苏南地区汉族人群CRP+1444C/T基因多态性与血清CRP水平无相关性。Objective：To investigate the correlation between C-reactive protein（CRP） gene ＋1444C/T polymorphism with the risk of unstable angina pectoris（UAP） and the serum CRP level in the ethnic Sunan Han population of China.Methods：The serum level of CRP was measured by enzyme-linked immunosorbent assay and the CRP gene ＋1444C/T polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism between 172 patients with UAP and 230 control subjects.Results：① There was CRP gene ＋1444C/T polymorphism in this study population;② The serum CRP level in UAP patients（8.269/9.179 μg/ml） was significantly higher than those in control subjects（3.578/2.236 μg/ml）（P 〈0.001） and multivariate logistic regression analysis showed that the serum CRP level was a risk factor of UAP;③ There was not difference in the serum CRP level in any genotypes of the CRP gene ＋1444C/T polymorphism between the UAP group and the control group（P 〈0.05） and further grouped by gender and age.Conclusion：There was no relationship between CRP gene ＋1444C/T polymorphism with its serum level in the ethnic Sunan Han population of China.

关 键 词：不稳定型心绞痛 C-反应蛋白 基因多态性 +1444C/T 血清CRP水平 

分 类 号：R541.4[医药卫生—心血管疾病]