3.0T MR ADC值与T2值定量测量在颈部淋巴瘤诊断价值的研究  

Quantitative measurement of ADC value and T2 value in diagnosis of cervical lymphoma at 3.0 T MRI

作　　者：龚红霞[1] 路青[1] 朱炯[1] 范瑜[1] 许建荣[1] 

机构地区：[1]上海交通大学医学院仁济医院放射科,上海200127

出　　处：《磁共振成像》2012年第5期367-371,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然基金(编号:81171325);上海市科委医学引导项目(编号:114119a0900);仁济医院学科建设第四期:以分子生物学和影像为依据的非霍奇金淋巴瘤个性化循证诊断及治疗(编号:RJ4101306)

摘　　要：目的比较3.0T MR ADC值及T2值定量测量在颈部淋巴瘤诊断中的价值。材料与方法对24例颈部淋巴瘤初发患者(初发组)及24例正常对照组进行MRI及ADC值和T2值的测量,淋巴瘤病例在治疗3个月后作为治疗后组再次进行扫描及测量。ADC值及T2值由ADC图和T2图直接获得。用LSD检验进行组间两两比较。结果在DWI上,无论是淋巴瘤患者或正常志愿者,淋巴结均呈高信号,在ADC图上呈低信号。在T2扫描序列,在不同的T2回波时间,淋巴结呈高信号,T2图上淋巴结呈等信号。ADC值和T2值在淋巴瘤初发组、治疗后组及正常对照组之间分别为(745.92±109.74)×10-6mm2/s和(87.18±9.35)ms,(1303.97±276.59)×10-6mm2/s和(93.30±11.21)ms,(1116.91±82.08)×10-6mm2/s和(96.44±4.40)ms;除T2值在治疗后组与正常对照组间差异无统计学意义(P>0.05),其余两两比较,差异均有统计学意义(P<0.05)。根据ROC曲线,区分淋巴瘤患者及正常对照的ADC值最佳诊断界值是1003.065×10-6mm2/s,此时敏感度为100%,特异度为91.7%。T2值的最佳诊断界值90.92ms,此时敏感度为62.5%,特异度为91.7%。结论 3.0TMRADC值和T2值定量测量是颈部淋巴瘤诊断的重要测量指标。ADC值的诊断敏感度及特异度优于T2值。.Objective：This study was designed to compare the value of quantitative measurement of ADC value and T2 value in diagnosis of lymphoma at 3.0 T MRI.Materials and Methods：Twenty-four cervical lymphoma patients（incipient group） characterized by superficial lymph node enlargement and 24 healthy volunteers were studied.Twenty-four cervical lymphoma patients performed MRI examination and quantitative measurement again after 3 months normal treatment.Imaging were performed on a 3.0 T MR imaging system.The measurements of ADC value and T2 value were performed from trace ADC maps and T2 maps by placing regions of interest（ROI） over the cervical lymph nodes.Comparison between groups with LSD test.Results：Either lymphoma patients or normal control,all lymph nodes showed high intensity on DWI images and low intensity on ADC maps.On T2 value image the lymph nodes showed high intensity in all different TE value images,median intensity onT2 map.The ADC value and T2 value among incipient group,posttreatment group and normal control were（745.92±109.74）×10-6 mm 2 /s and（87.18±9.35） ms,（1303.97±276.59）×10-6 mm 2 /s and（93.30±11.21） ms,（1116.91±82.08）×10-6 mm 2 /s and（96.44±4.40） ms.There were significant statistical difference among all of them except for T2 value between posttreatment group and normal control.The optimal threshold ADC value and T2 value for differentiating normal and malignant cervicallymph nodes determined by ROC curve analysis were showed 1003.065×10 6 mm 2 /s and 90.92 ms.Applying this value resulted in a sensitivity of 100% and 62.5%,a specificity of 91.7% and 91.7%.Conclusion：The quantitative measurements of ADC value and T2 value at 3.0T MRI were important indicator in diagnosis of cervical lymphoma.The diagnostic sensitivity and specificity of ADC value was superior to T2 value.

关 键 词：头颈部肿瘤 淋巴瘤 磁共振成像 弥散 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.91[医药卫生—诊断学]