磁共振扩散张量成像对肝硬化患者脊髓病变早期诊断的初步研究  

Preliminary study of DTI in the early diagnosis of cirrhosis patients with spinal cord lesions

作　　者：牛金亮[1] 黄椿尧[1] 王峻[1] 田雪[1] 

机构地区：[1]山西医科大学第二医院影像科,太原030001

出　　处：《磁共振成像》2012年第5期379-382,共4页Chinese Journal of Magnetic Resonance Imaging

基　　金：山西省科技攻关项目(编号:20110313013-4;20110313013-1)

摘　　要：目的探讨MR扩散张量成像(DTI)平均扩散系数(DCavg)和各向异性分数(FA)值对肝硬化患者脊髓病变早期诊断的价值。材料与方法 45例肝硬化患者按Child-Pugh分级标准,分为A、B和C级(组)患者各15例;选取15例正常健康志愿者为对照组(D组)。所有受试者均行胸腰段脊髓DTI,b=500s/mm2,扩散敏感梯度为25个方向。原始数据后处理重建出DCavg和FA伪彩图,并测量其值。A、B、C、D组间比较采用方差分析,组间两两比较采用Bonferroni法,对照组与肝硬化组比较采用t检验。结果 15例正常对照组胸腰段脊髓DCavg值为(1.330±0.160)×10-3mm2/s,FA值为0.320±0.150;45例肝硬化组胸腰段脊髓DCavg值为(1.415±0.250)×10-3mm2/s,FA值为0.404±0.110,两组DCavg值、FA值差异有统计学意义(t值分别为4.896、16.456,P值均<0.05);A、B、C组患者胸腰段脊髓DCavg值分别为(1.342±0.100)×10-3mm2/s、(1.371±0.230)×10-3mm2/s和(1.492±0.290)×10-3mm2/s,FA值分别为0.353±0.110、0.385±0.130和0.446±0.090;A、B、C、D组四组间比较,DCavg、FA值差异有统计学意义(P值均<0.05);组间两两比较,C组患者DCavg、FA值较A、B及D组高,差异具有统计学意义(P<0.05)。A组与D组DCavg、FA值差别无统计学意义(P值均>0.05)。结论肝硬化患者胸腰段脊髓DTI的DCavg和FA值较正常人增高,DTI能为肝硬化患者脊髓病变的早期诊断、病情评估提供信息。.Objective：To investigate the value of early diagnosis of the average diffusion coefficient（DC avg） and fractional anisotropy（FA） of the magnetic resonance diffusion tensor imaging（DTI） in hepatic cirrhosis patients with spinal cord lesions.Materials and Methods：According to the standard of Child-Pugh classification,select A,B and C-class（group） patients（15 cases respectively） and 15 cases of normal healthy volunteers as controls（Group D）.All the subjects accept thoracolumbar spinal DTI scan,b=500 s/mm 2,25 different directions of diffusion gradient.Reconstruct the DC avg and FA pseudo-color pictures by the post-processing of raw data and measure its value.Analysis of variance is used for the comparison of A,B,C,D group,the Bonferroni is used for the multiple comparison between groups,t test is used for the comparison between the control group and the hepatic cirrhosis group.Results：The value of DC avg of thoracolumbar spinal in normal control group（15 cases） is（1.330±0.160） ×10-3 mm 2 /s,the value of FA is 0.320±0.150,the value of DC avg of thoracolumbar spinal in hepatic cirrhosis group（45 cases） is（1.415±0.250） × 10-3 mm 2 /s,the value of FA is 0.404±0.110,the difference of the value of DC avg and FA between the two groups are significant（t=4.896,P0.05,t=16.456,P0.05）.The valueof DC avg of thoracolumbar spinal cord in A,B,C group are respectively（1.342±0.100） ×10-3 mm 2 /s,（1.371±0.230） ×10-3 mm 2 /s,（1.492±0.290） ×10-3 mm 2 /s,the value of FA are respectively 0.353±0.110,0.385±0.130,0.446±0.090.The difference of the value of DC avg and FA among the groups is significant（P0.05）.The value of DC avg and FA in group C are higher than the Group A,B and D,the difference is significant（P0.05）.The difference of the value of DC avg and FA between Group A and D is no significant difference（P0.05）.Conclusions：Compared with the normal,the value of DTI DC avg and FA of thoracolumbar spinal cord values in patients with hepatic cirrhos

关 键 词：脊髓疾病 磁共振成像 扩散 肝硬化 

分 类 号：R445.2[医药卫生—影像医学与核医学] R744[医药卫生—诊断学]