肝素联合硫酸镁治疗慢性肺心病疗效观察  

The Effect of Heparin and Sulfate Magnesium in Treatment of Patients with Chronic cor pulmonale

作　　者：李艳[1] 陈维永[1] 柯华[1] 

机构地区：[1]成都市第七人民医院,四川成都610021

出　　处：《现代临床医学》2012年第5期342-343,共2页Journal of Modern Clinical Medicine

摘　　要：目的:观察肝素与硫酸镁联合治疗慢性肺心病并呼吸衰竭的临床疗效。方法:将69例慢性肺心病患者随机分为治疗组35例和对照组34例,2组患者均常规给予抗感染、吸氧、止咳祛痰、解痉平喘、强心利尿、纠正电解质紊乱等治疗,治疗组在此基础上加用肝素及硫酸镁,治疗7天后观察疗效。结果:治疗组总有效率为94.3%,对照组总有效率为73.5%,治疗组的疗效明显优于对照组(P<0.05),治疗组血液流变学改善程度优于对照组(P<0.01)。结论:肝素联合硫酸镁治疗慢性肺心病患者安全有效,能改善心肺功能,改善肺心病患者预后,副作用小,可在临床推广应用。Objective：To investigate the effect of heparin combined with sulfate magnesium in treating chronic cor pulmonale. Methods ：69 patients were randomly divided into treatment group （n = 35 ） and control group （n = 34）. Two groups were treated with antibiotics, oxygen uptake, and the medicines of relieving cough and phlegm, bronchial antispasmodic, cardiotonic, diuretic ; meanwhile corrected the disturbance of electrolytes and so on. In addition, the patients in the treatment group were given heparin and sulfate magnesium for 7 days. Observed the therapeutic effect of the two groups. Results：The total clinical effective rate in treatment group was 94. 3% , but in control group was 73. 5%. The difference was significant （ P 〈 0. 05 ）. The improvement of hemorheology indexes in treatment group was better than in control group （ P 〈 0. 01 ）. Conclusion：Combining heparin with sulfate magnesium in the treatment of chronic cor pulmonale is a safe and effective method. It can remarkably improve the cardiac and respiratory function, and have few adverse reactions ,which can be adopted in clinic.

关 键 词：肝素 硫酸镁 肺心病 呼吸衰竭 

分 类 号：R541.5[医药卫生—心血管疾病]