精浆锌含量与精液质量及体外受精结局的相关性  

Correlation between seminal plasma Zinc concentration and semen quality,outcomes of in vitro fertilization

作　　者：江莉[1] 李慕军[1] 牛冉冉[1] 翟丹梅[1] 袁华[1] 

机构地区：[1]广西医科大学第一附属医院,南宁530021

出　　处：《山东医药》2012年第35期22-24,共3页Shandong Medical Journal

基　　金：广西卫生厅重点科研课题(桂卫重200846);广西教育厅高等学校科研项目(200103YB023)

摘　　要：目的探讨精浆锌含量对精液质量及体外受精(IVF)结局的影响。方法采用5-Br-PAPS显色法检测81例不育男性患者精浆锌含量,Spearman相关分析法分析精浆锌含量与精液常规参数、成熟精子率及IVF结局的关系。结果 Spearman相关分析显示精浆锌含量与精子密度、精子活率、IVF受精数呈显著正相关(r=0.49、0.305、0.289,P均<0.05,与不成熟精子率呈负相关(r=-0.278,P<0.05),与精子正常形态率及IVF卵裂率、优胚率无相关性(P均>0.05)。结论适量的精浆锌含量能够促进精子核成熟,精浆锌含量降低可致精子密度和活率下降,使IVF受精数降低;但是对精子的正常形态率,IVF卵裂率和优质胚胎率无显著影响。Objective To investigate the relationship between seminal plasma Zinc concentration and sperm quality, outcomes of in vitro Fertilization. Methods The seminal plasma Zinc concentration of 81 infertile men was detected by using 5-Br-PAPS staining method. Spearman correlation between seminal plasma Zinc, conventional semen parameters and IVF fertilization rates, cleavage rate, and good quality embryo rate was analyzed. Results A significant positive correlation was found between seminal plasma Zinc concentration with sperm density, motility and IVF fertilization rate （r = 0. g9, 0. 305, 0.289 ; all P 〈 0.05） ; but was negatively correlated with immature sperm rate（ r = - 0. 278, P 〈 0.05 ）. However, no correlation was found between seminal plasma Zinc concentration and cleavage rate, good quality embryo rate（ all P 〉 0. 05 ）. Conclusion Amount of seminal plasma zinc level can promote the maturation of sperm nuclear. Seminal plasma zinc content can decrease sperm density and motility, and also can decrease IVF fertilization rate; bnt no significant impact can be seen to the normal sperm morphology, IVF embryo cleavage rate and quality rate.

关 键 词：精浆 锌 精液质量 体外受精 

分 类 号：R698.2[医药卫生—泌尿科学]