首参颗粒对颈动脉粥样硬化患者临床疗效的初步评价  

The Preliminary Evaluation of the Clinical Curative Effect on Carotidatherosclerosis Patients for Shoushen Granules

作　　者：申定珠[1] 赵红彬[1] 邢三丽[1] 楼丹飞[2] 沈睿[2] 刘特[1] 陈久林[1] 迟惠英[1] 梁珍珍[1] 李越华[2] 陈川[1] 

机构地区：[1]上海市中医老年医学研究所 [2]上海市中医医院

出　　处：《中国中医急症》2012年第10期1559-1561,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：上海市卫生局局级科研项目(2010225;20114047);上海市卫生局中医药科研基金项目(2010L046A);上海市教委预算内科研项目(09JW45)

摘　　要：目的观察补肾中药复方首参颗粒对颈动脉粥样硬化患者的临床疗效。方法将80例患者随机分为两组,对照组口服普伐他汀,治疗组服用首参颗粒,疗程均为6个月。于治疗前后采用彩色多普勒超声检测颈动脉硬化患者颈动脉内膜-中层厚度(IMT),动脉硬化仪检测肱踝脉搏波传导速度(baPWV),并观察用药前后患者的血脂变化及肝、肾功等安全性指标。结果治疗后6个月,对照组IMT、TC、TG、LDL-C及TC/HDL-C比值较治疗前均明显降低,HDL-C较治疗前明显升高;治疗组baPWV较治疗前明显降低,TG、TC/HDL-C比值较治疗前降低,HDL-C较治疗前明显升高。结论首参颗粒可通过降低IMT、baPWV及改善脂质代谢进而有效干预治疗颈动脉粥样硬化病变。Objective： To observe the clinical curative effect of compound Chinese medicine for reinforcing kidney shoushen granules on carotid atherosclerosis in patients.Methods： 80 patients were randomly divided into two groups.The control group was treated with pravastatin,treatment group took shoushen granules,the treatment course is 6 months.Before and after the treatment with color Doppler ultrasound detection of carotid atherosclerosis in patients with carotid artery intima-media thickness（IMT）,arteriosclerosis detection brachial ankle pulse wave velocity（baPWV） before and after treatment were observed,and the changes of blood lipid in patients with hepatic,renal function and safety index.Results： after 6 months of treatment,the control group IMT,TC,TG,LDL-C and TC/HDL-C ratio were significantly lower than that before treatment,HDL-C significantly increased;baPWV in treatment group was significantly lower than that before treatment,TG,TC/HDL-C were lower than those before therapy,HDL-C significantly increased.Conclusion： the shoushen granules can reduce the IMT,baPWV and improve lipid metabolism and effective intervention for the treatment of carotid atherosclerosis.

关 键 词：首参颗粒 颈动脉粥样硬化 颈动脉内膜-中层厚度 肱踝脉搏波传导速度 

分 类 号：R543.5[医药卫生—心血管疾病]