转化生长因子-β1与结缔组织生长因子在类风湿关节炎合并肺间质病变患者血清中的表达水平及临床意义  

Expression Levels of Serum TGF-β1 and CTGF in Patients with Rheumatoid Arthritis Complicated by Interstitial Lung Disease the Significance

作　　者：闫慧明[1] 丁利芳[1] 刘媛[1] 庞春艳[1] 王永福[1] 

机构地区：[1]包头医学院风湿免疫研究所,内蒙古自治区包头市014010

出　　处：《中国全科医学》2012年第28期3268-3270,共3页Chinese General Practice

摘　　要：目的通过检测转化生长因子-β1(TGF-β1)、结缔组织生长因子(CTGF)在类风湿关节炎合并肺间质病变(RA-ILD)患者血清中的表达水平,来探讨其在肺间质病变(ILD)中的临床意义。方法采用酶联免疫吸附(ELISA)法检测类风湿关节炎(RA)100例患者(其中单纯RA患者55例,RA-ILD患者45例)和50例健康对照者血清中TGF-β1和CTGF的表达水平。结果 RA-ILD组患者血清中TGF-β1和CTGF的含量均高于单纯RA组和健康对照组,差异有统计学意义(P<0.05)。RA-ILD组中TGF-β1(r=0.410,P=0.005)和CTGF(r=0.330,P=0.029)与C-反应蛋白(CRP)水平呈正相关。结论 TGF-β1、CTGF的表达水平与RA-ILD发生相关,并且可能是通过介导CRP的水平升高来参与RA-ILD的发生。TGF-β1、CTGF可作为筛查RA-ILD的早期指标之一。Objective To determine the expression levels of serum levels of transforming growth factor - β1 （TGF - β1 ） and connective tissue growth factor （CTGF） in patients with rheumatoid arthritis complicated by interstitial lung disease （ RA - ILD） so as to explore their clinical significance in ILD. Methods The serum levels of TGF - β1, CTGF in 100 RA patient （ including 55 simple RA patients and 45 RA - ILD patients） and 50 healthy volunteers were detected by enzyme linked immu- nosorbent assay （ELISA） . Results The serum levels of TGF - β1, CTGF in patients in the RA - ILD group were statistically higher than those in the RA group and control group （P 〈0. 05）. In the RA -ILD group the C -reactive protein was positively correlated with TGF - β1 （ r = 0.41, P = 0. 005 ） and CTGF （ r = 0. 33, P = 0. 029 ）. Conclusion The serum levels of TGF - 131 and CTGF were related with development of RA - ILD, and they may take part in the pathogenesis of RA - ILD by increasing the levels of C - reactive protein. So the levels of TGF - β1 and CTGF may be one of the early markers to screen RA - ILD.

关 键 词：转化生长因子-Β1 结缔组织生长因子 类风湿关节炎 肺间质病变 

分 类 号：R593.22[医药卫生—内科学] R563[医药卫生—临床医学]