基于poly(N-isopropylacrylamide)的温度敏感性胶束作为抗肿瘤药物载体的研究进展  

Advances on the Research of Thermosensitive Micelles Based on PNIPAAm as Drug Carriers

作　　者：金靖[1] 顾月清[1] 

机构地区：[1]中国药科大学生物医学工程实验室,江苏南京210009

出　　处：《药物生物技术》2012年第5期453-457,共5页Pharmaceutical Biotechnology

摘　　要：PNIPAAm广泛应用于温敏敏感性胶束的构建中。文章总结了近年来用于肿瘤药物传递的基于PNIPAAm温敏材料的胶束的结构设计,合成方法以及应用方面的最新研究进展。The purpose is to review the progress in research of structure design, synthesis methods and applications of thermosensitire micelles based on PNIPAAm as anticancer drug delivery. A large number of excellent methods are used to design new structure forming thermosensitive micelles based on the PNIPAAm. And some new applications are raised to meet the needs of better anticancer ability and to overcome the disadvantages of the exsiting mehods. The development of thrmosensitive micelles based on PNIPAAm promotes the smart drug nanocarrier＇ progress greatly.

关 键 词：聚异丙基丙烯酰胺 聚合物胶束 药物载体 

分 类 号：R979.1[医药卫生—药品]