不同泽兰提取液的成膜材料筛选  

Screening of Film Forming Material for Different Extraction Liquid of Lycopus lucidus

作　　者：魏刚[1] 许日鑫[1] 何坦 林华燕[1] 林微微[1] 石添香[1] 欧斯健[1] 刘东辉[1] 

机构地区：[1]广州中医药大学,广州510405 [2]广州中一药业有限公司,广州510130

出　　处：《中国实验方剂学杂志》2012年第21期19-24,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技部"十一五"科技支撑计划项目(2008BAI53B074);广东省教育部产学研结合项目(2011B090400319);广东高校科技成果转化重大项目(cgzhzd1009)

摘　　要：目的:考察主要成膜材料在泽兰水提液和乙醇提取液中的成膜性能,为含泽兰的中药喷膜剂成膜材料的选择与应用提供参考。方法:根据成膜材料的溶解性,选择聚乙烯吡咯烷酮(PVP)、聚乙烯醇(PVA)、乙基纤维素(EC)、甲基纤维素(MC)等成膜材料,通过显微镜和图像拍摄软件对膜结构拍照分析,考察各成膜材料在泽兰水提液和不同体积分数乙醇提取液中成膜性能。结果:PVP-K30,PVP-K90在泽兰水提液及乙醇提取液中均具有良好的成膜性,且膜的质地细密、光滑、平整。PVA-1788在泽兰水提液及乙醇提取液中均能成膜,但膜表面凹凸不平、较粗糙,且有少量颗粒分散在膜表面;EC在泽兰无水乙醇提取液中成膜性能优良,能形成一层厚实、平整、致密的膜,但EC-6-9,EC-9-11在泽兰80%乙醇提取液中成膜性较差,其膜结构较不明显;MC在泽兰提取液中成膜性随提取液乙醇体积分数升高而降低。结论:成膜材料的选择与泽兰提取液溶媒极性有关,PVP-K30是含泽兰的中药喷膜剂、膜剂等成膜材料的最优选择。Objective： To investigate film-forming property of main film-forming materials in water and ethanol extraction liquid of Lycopus lucidus, and to provide a reference for selection and application of film-forming materials from Chinese medicine spray including L. lucidus. Method： According to solubility of film-forming materials, polyvinyl pyrrolidone （PVP）, polyvinyl alcohol （PVA）, ethyl cellulose （EC） and methyl cellulose （MC） were used to investigate property of film-forming materials in different extraction solution of L. lucidus by picture analyzing membrane structure with microscope and image capture software. Result： PVP-K30 and PVP- K90 had a goof film-forming ability with a fine texture, smooth and neat membrane. PVA-1788 would form membrane in water and ethanol extraction liquid of L. lucidusin, but membrane surface was uneven and rough with a small amount of particles. MC-400 and MC-1500 could from a layer of thick, smooth, dense membrane with excellent film-forming property in different extraction solution of L. lucidusin, but EC-9-11 and EC-6-9 had poor film-forming properties in 80% ethanol extraction liquid of L. lucidusin, membrane structure was unobvious, film- forming property of MC decreased with increasing ethanol concentration from extraction liquid of L. lucidusin. Conclusion： Polarity of solvent showed relationship with selecting of film-forming materials, PVP-K30 was optimum film-forming material for Chinese medicine spray and film agent including L. lucidusin.

关 键 词：泽兰 提取液 成膜材料 膜剂 喷雾剂 

分 类 号：R283.6[医药卫生—中药学]