参芎葡萄糖注射液治疗血管性痴呆的疗效及对AVP的影响  

Clinical Research of Shenxiong Glucose Injection Treating Vascular Dementia and Influence on AVP

作　　者：何金波[1] 金杰[2] 

机构地区：[1]河南中医学院,郑州450000 [2]河南中医学院第一附属医院,郑州450000

出　　处：《中国实验方剂学杂志》2012年第21期306-310,共5页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:评价参芎葡萄糖注射液治疗轻、中度瘀血阻络型血管性痴呆的临床疗效,并探讨其对精氨酸加压素(AVP)的影响。方法:将60例血管性痴呆患者随机分为治疗组30例和对照组30例,在基础药物治疗基础上,治疗组予以参芎葡萄糖注射液(200 mL/次,1次/d)静脉输液;对照组给予舒血宁注射液(20 mL/次,1次/d)静脉输液,疗程均为28 d。观察患者简易精神状态检查(MMSE),ADL,中医证候,血液流变学指标和AVP含量变化。结果:①两组MMSE,ADL,中医症状积分组内治疗前、中、后比较,与时间相关,经统计学分析组内差异均有显著性意义(P<0.05),提示两组均能改善MMSE,ADL,中医症状积分;②治疗后两组的MMSE,ADL,中医证候积分组间比较无显著性差异;③两组组内治疗前后比较,在全血高切黏度、低切黏度、血浆黏度、红细胞聚集指数、纤维蛋白原方面有明显降低作用(P<0.05),提示两组均能改善血液流变性;但参芎葡萄糖注射液在降解纤维蛋白原方面优于舒血宁注射液。④治疗组治疗后血浆AVP含量较治疗前明显升高(P<0.05),对照组治疗前后无明显变化,提示治疗组对AVP有影响。结论:参芎葡萄糖注射液治疗轻、中度VD有较好的疗效,与AVP呈相关性。Objective： To evaluate the clinical effect of Shenxiong glucose injection on vascular dementia and arginine vasopressin （AVP）. Method： We chose 60 cases hospitalized patients according to the selection criteria, and randomLy divided into the treatment group of 30 cases and control group of 30 cases. On the basis of cell diphosphate choline sodium injection, the treatment group was given Shenxiong Glucose injection 200 mL, once daily, the control group was give Shuxuening injection 20 mL, once daily. The course lasted for 28 days. patients＇ MMSE, ADL, Chinese medicine symptom scores, hemorrheologic indices and AVP content were observed. Result： ① In MMSE, ADL, Chinese medicine symptom scores before and after treatment, there was significant differences （P 〈 0.05） between two groups; ②In MMSE, ADL, Chinese medicine symptom scores after treatment of one day between the two groups there was no significant difference; ③the whole blood viscosity, plasma viscosity, the red cell aggregation index, fibrinogen after treatment showed significant difference （P 〈 0.05） , suggesting two groups can both improve blood rheology; But action of Shengxiong glucose injection was better than Shuxuening in degrading fibrinogen. ④In treatment group plasma AVP content onday 29 of treatment is higher significantly than before treatment （P 〈 0.05） , and the control group has no obvious changes, indicating that the treatment group have an effect on AVP. Conclusion： Shenxiong glucose injection has a good effect on VD patient, which is correlate with AVP.

关 键 词：血管性痴呆 瘀血阻络证 精氨酸加压素(AVP) 参芎葡萄糖注射液 

分 类 号：R285[医药卫生—中药学]