Cucurbit[7]uriI-Based Vesicles Formed by Self-assembly of Supramolecular Amphiphiles  

作　　者：李佳锡 周黎鹏 罗全 王永国 张春秋 卢伟 徐家云 刘俊秋 

机构地区：[1]Key Laboratory of Supramolecular Structure and Materials College of Chemistry,Jilin University,Changchun,Jilin 130012,China

出　　处：《Chinese Journal of Chemistry》2012年第9期2085-2090,共6页中国化学（英文版）

摘　　要：Cucurbituril （CB）, a well-known macrocyclic cavitand, has been used extensively to construct supramolecular aggregates. Based on host-guest intertactions, an adamantanyl derivative guest molecule was designed and syn- thesized to prepare a supramolecular amphiphile with cucurbit[7]uril. In aqueous solution, the cucurbit[7]uril based supramolecular amphiphiles self-assemble into well-defined vesicles, and their disassembly can be achieved by addition of excess competitive agent 1-adamantanamine hydrochloride. This vesicle functions as a new nanocapsule to encapsulate molecules within its hollow cavity. Through competitive disassembly of supramolecular amphiphiles, the vesicles behave as a novel drug delivery carrier.Cucurbituril （CB）, a well-known macrocyclic cavitand, has been used extensively to construct supramolecular aggregates. Based on host-guest intertactions, an adamantanyl derivative guest molecule was designed and syn- thesized to prepare a supramolecular amphiphile with cucurbit[7]uril. In aqueous solution, the cucurbit[7]uril based supramolecular amphiphiles self-assemble into well-defined vesicles, and their disassembly can be achieved by addition of excess competitive agent 1-adamantanamine hydrochloride. This vesicle functions as a new nanocapsule to encapsulate molecules within its hollow cavity. Through competitive disassembly of supramolecular amphiphiles, the vesicles behave as a novel drug delivery carrier.

关 键 词：SELF-ASSEMBLY CUCURBITURIL vesicles supramolecular amphiphiles drug delivery 

分 类 号：O641.3[理学—物理化学] O647.2[理学—化学]