血清铅与冠心病关系的meta分析  

The Meta-andlysis of serum lead and Coronary Heut Disease

作　　者：彭正同[1] 陈冬峨[1] 贺志锐[1] 王瑾瑶[1] 

机构地区：[1]武汉大学公共卫生学院流行病与卫生统计学系,湖北430071

出　　处：《社区医学杂志》2012年第20期1-2,共2页Journal Of Community Medicine

摘　　要：目的探讨冠心病患者的血铅浓度和一般人群是否有差异。方法检索纳入国内外有关微量元素与冠心病关系的文献4篇,采用meta分析的方法,应用随机效应模型进行综合定量分析,计算合并效应值及可信区间,利用倒漏斗图定性评价发表性偏倚。结果合并效应量等于0.03,总的可信区间[0.01 0.06],冠心病患者血铅浓度要高于对照组。由于meta分析结果不符合要求,所以未进行倒漏斗图分析。结论铅为本次研究的危险因素,提示微量元素铅和冠心病间可能存在关联。Objective To study where there is any correlation between coronary heart disease and serum lead.Methods Four papers about relation between CHD and serum lead were collected,and the data were quantitatively analyzed with random effect models,Merger effect value or CI was calculated,and the published bias was assessed qualitatively by funnel plots.Results Merger effect quantity is equal to 0.03,The total confidence interal is [0.01 0.06],CHD patients blood lead levels higher than the control group.Due to Meta analysis results do not conform to the requirements,So do not make funnel plots.Conclusions Lead is the risk factor of the research,prompting there is a connection between microelement and CHD.

关 键 词：血清铅 冠心病 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]