自身免疫性甲状腺疾病患者血清C1q抗体的变化  

Serum Anti-C1q Antibodies in Patients with Autoimmune Thyroid Disease

作　　者：徐明彤[1] 姜力丹[1] 黎锋[1] 唐菊英[1] 薛声能[1] 柴佳妮[1] 严励[1] 

机构地区：[1]中山大学孙逸仙纪念医院内分泌科,广东广州510120

出　　处：《中山大学学报（医学科学版）》2012年第5期664-667,共4页Journal of Sun Yat-Sen University:Medical Sciences

摘　　要：【目的】了解自身免疫性甲状腺疾病患者血清C1q抗体水平,探讨血清C1q抗体水平与甲状腺功能、甲状腺自身抗体的关系。【方法】采用ELISA方法测定28例Graves病患者(GD组)、34例慢性淋巴细胞性甲状腺炎患者(CLT组)和27例正常对照(CON组)血清C1q抗体水平。【结果】CON组、GD组和CLT组血清C1q抗体水平分别为:3.130(2.773～3.833)U/mL、4.625(2.888～11.798)U/mL和3.125(2.750～4.625)U/mL。GD组的C1q抗体水平显著高于CON组(P<0.05),阳性率也显著高于CON组(46.4%vs 7.4%,P<0.05);C1q抗体水平与TRAb水平呈正相关(r=0.436,P=0.029)。CLT组C1q抗体与TT4水平呈负相关(r=-0.351,P=0.045)。【结论】本研究Graves病患者血清C1q抗体水平显著升高,与TRAb呈正相关;慢性淋巴细胞性甲状腺炎患者血清C1q抗体水平与血清甲状腺素水平呈负相关。[Objective] To investigate serum anti-Clq antibodies （Clq Ab） levels in the patients with autoimmune thyroid disease, and the correlation between serum levels of Clq Ab and thyroid function, thyroid auto-antibodies is analyzed. [ Methods ] The serum levels of Clq Ab in 28 Graves disease patients （GD group）, 34 in chronic lymphocytic thyroiditis patients （CLT group） and 27 healthy subjects （CON group） were detected by enzyme-linked immunosorbent assay （ELISA）. [Results] Serum levels of Clq Ab were 3.130 （2.773-3.833） U/mL in the CON group, 4.625 （2.888-11.798） U/mL in the GD group and 3.125 （2.750-4.625） U/ mL in the CLT group respectively. Patients with GD were positive more frequently for anti-Clq than controls. Absolute values of serum anti-Clq levels in the GD group were higher than that in the CON group, and correlated positively with TRAb. However, serum levels of C l q Ab in the CLT group showed a negative correlation with TY4. [ Conclusions ] Serum levels of C l q Ab in the GD group were higher than that in the CON group, and correlated positively with TRAb. And serum levels of C lq Ab in the CLT group correlated negatively with TF4.

关 键 词：C1Q抗体 GRAVES病 慢性淋巴细胞性甲状腺炎 

分 类 号：R581[医药卫生—内分泌]