补肾壮骨冲剂对老年男性骨量减少及骨质疏松患者骨代谢指标影响的临床观察  

Clinical observation of the effect of Bushen Zhuanggu Granules on bone metabolic markers in senile male patients with low bone mass and osteoporosis

作　　者：叶竹[1] 刘坚[1] 王应立[1] 韩炜[1] 宋骤[1] 杨健[1] 韩丽萍[1] 邓伟民[1] 

机构地区：[1]广州军区广州总医院,广州510010

出　　处：《中国骨质疏松杂志》2012年第10期887-891,共5页Chinese Journal of Osteoporosis

基　　金：军队中医药科研专项课题重点项目(10ZYZ115);广东省科学技术厅-广东省中医药科学院联合科研专项(2011B032200005)

摘　　要：目的通过比较补肾壮骨冲剂组服药前、服药半年后骨密度及骨代谢指标的变化情况,并将补肾壮骨冲剂组与阿仑膦酸钠及钙尔奇D组分别作对比,观察补肾壮骨冲剂治疗老年男性骨量减少及骨质疏松、改善其骨代谢的临床疗效。方法采用电化学发光免疫分析法分析血清中PINP、β-Crosslaps及N-MID的含量;采用美国GE公司生产的Lunar Prodigy双能X线(DXA)骨密度仪,检测各部位BMD;将研究对象按就诊时间分为3组,补肾壮骨冲剂组服用补肾壮骨冲剂+钙尔奇D,阿仑膦酸钠组服用阿仑膦酸钠+钙尔奇D,钙尔奇D组只服用钙尔奇D。结果补肾壮骨冲剂组治疗半年后血清中的PINP、β-Crosslaps及N-MID下降显著;与治疗前相比,左侧股骨颈、Ward三角和左侧股骨近端处的BMD提高明显;补肾壮骨冲剂组改善老年男性骨代谢及提高骨密度的效果优于钙尔奇D组;与临床疗效公认的阿仑膦酸钠组比较,补肾壮骨冲剂显示出与其相近的改善骨代谢和提高骨密度疗效。结论补肾壮骨冲剂是治疗老年性骨量减少及骨质疏松、提高骨量、改善老年男性骨代谢情况的安全有效药物。Objective By comparing the changes of bone mineral density （BMD） and bone metabolic markers before and after the treatment with Bushen Zhuanggu Granules for half a year, and comparing the effect among Bushen Zhuanggu Granules group, alendronate sodium group, and Cahrate D group, the clinical efficacy of Bushen Zhuanggu Granules on low bone mass, osteoporosis, and bone metabolism in senile male patients was observed. Methods The serum levels of PINP, β-Crosslaps, and N-MID were tested using electrochemiluminescence immunoassay. BMD of different locations was measured using Lunar Prodigy dual energy X ray （DXA, GE Co. , USA）. All the subjects were divided into 3 groups according to the time they came to the hospital. Patients in Bushen Zhuanggu Granules group were given Bushen Zhuanggu Granules ＋ Cahrate D. Patients in alendronate sodium group were given alendronate sodium tablets ＋ Caltrate D. And patients in Caltrate D group were given Cahrate D only. Results After a 6- month treatment, the serum levels of PINP, β-Crosslaps, and N-MiD in Bushen Zhuanggu Granules group decreased significantly. BMD of the femoral neck, Ward ＇s triangle, and the left femur increased significantly. Compared with Caltrate D group, Bushen Zhuanggu Granules group showed a better efficacy on improving bone metabolism and increasing BMD in elderly men, while compared with alendronate sodium treatment, Bushen Zhuanggu Granules showed a similar efficacy. Conclusion Bushen Zhuanggu Granules is safe and effective for the treatment of senile male patients with low bone mass and osteoporosis by increasing their bone mass and improving their bone metabolism.

关 键 词：补肾壮骨冲剂 骨质疏松 骨密度 I型原胶原氨基端前肽 B-胶原降解产物 N端骨钙素 

分 类 号：R285.6[医药卫生—中药学]