按需服用达泊西汀对早泄疗效的Meta分析  

Meta-analysis of dapoxetine on demand in the treatment of premature ejaculation

作　　者：罗艺洪[1] 侯祺[1] 郑少斌[1] 

机构地区：[1]南方医科大学附属南方医院泌尿外科,广东广州510515

出　　处：《中华男科学杂志》2012年第10期930-935,共6页National Journal of Andrology

摘　　要：目的:评价按需服用达泊西汀对早泄的疗效,为临床决策提供依据。方法:检索PubMed、Embase、BIOSIS Previews、Cochrane Library、CNKI数据库、万方资源数据库有关按需服用达泊西汀治疗早泄的研究文献,并进行Meta分析;主要评价阴道内射精潜伏时间(intravaginal ejaculatory latency time,IELT)、患者总体感觉改善情况(patient-reported global impression of change,PGI)、综合临床受益(composite PRO criteria for clinical benefit,CCCB)3项结局指标。结果:检索出相关文献159篇,剔除142篇,共有4篇文献符合纳入标准,累计患者6 081例。Meta分析结果显示:与安慰剂相比,按需服用达泊西汀在IELT[WMD=1.39,95%CI(1.23,1.55),P<0.000 01],PGI[OR=2.59,95%CI(2.21,3.04),P<0.000 01],CCCB[OR=2.59,95%CI(1.98,3.39),P<0.00001]方面差异均有显著性意义;达泊西汀60 mg与30 mg治疗组间比较,60 mg组在IELT[WMD=0.46,95%CI(0.19,0.74),P=0.0010],PGI[OR=1.32,95%CI(1.06,1.64),P=0.01]方面差异有显著性意义,在CCCB[OR=1.39,95%CI(0.90,2.15),P=0.13]方面无显著性差异。结论:本研究表明按需服用达泊西汀60 mg及30 mg均能延长早泄患者IELT,提高其PGI及改善CCCB;其中60 mg较30 mg剂量在延长早泄患者IELT及提高PGI方面效果更佳。Objective： To assess the efficacy of dapoxetine on demand for premature ejaculation and provide evidence for clinical decision-making.Methods： We searched PubMed,Embase,BIOSIS Previews,Cochrane Library,CNKI Database and Wanfang Database for literature on dapoxetine on demand for premature ejaculation.We performed meta-analysis on the identified publications and evaluated its therapeutic efficacy based on the intravaginal ejaculatory latency time（IELT）,patient-reported global impression of change（PGI）,and composite PRO criteria for clinical benefit（CCCB）.Results： Four relevant studies were included involving 6 081 cases of premature ejaculation.Compared with the placebo controls,the patients treated with dapoxetine on demand showed significant improvement in IELT（WMD=1.39,95% CI [1.23,1.55],P0.000 01）,PGI（OR=2.59,95% CI [2.21,3.04],P0.000 01）,and CCCB（OR=2.59,95% CI [1.98,3.39],P0.000 01）.There were significant differences between the 60 mg and 30 mg dapoxetine groups in IELT（WMD=0.46,95% CI [0.19,0.74],P=0.001 0） and PGI（OR=1.32,95% CI [1.06,1.64],P=0.01）,but not in CCCB（OR=1.39,95% CI [0.90,2.15],P=0.13）.Conclusion： Dapoxetine on demand can prolong IELT and improve PGI and CCCB,either at the dose of 60 mg or 30 mg,and has an even better efficacy in prolonging IELT and improving PGI at 60 mg.

关 键 词：达泊西汀 早泄 治疗 随机对照试验 META分析 

分 类 号：R698[医药卫生—泌尿科学]