常染色体显性多囊肾病患者652次住院原因分析  

Causes analysis of 652 hospital stays in patients with autosomal dominant polycystic kidneydisease

作　　者：戎殳[1] 马熠熠[1] 陈冬平[1] 张彤[1] 孙海棚[1] 贺靓靓[1] 李兰君[1] 陈舟[1] 程烨[1] 李林[1] 孙丽君[1] 徐成钢[1] 郁胜强[1] 赵学智[1] 叶朝阳[1] 梅长林[1] 

机构地区：[1]第二军医大学上海长征医院肾内科、解放军肾脏病研究所,上海200003

出　　处：《中华肾脏病杂志》2012年第10期769-774,共6页Chinese Journal of Nephrology

基　　金：上海市重点学科建设项目（B902）

摘　　要：目的分析常染色体显性多囊肾病（ADPKD）患者住院原因，探讨延缓ADPKD进展的措施。方法收集1990年1月1日至2010年12月311321年间本院收住院的所有ADPKD患者病历资料，统计住院原因，并分析不同年龄、性别和住院时期住院原因的差异。结果（1）652例次住院中，ADPKD患者最常见的住院原因为腰腹痛（15．2％），其次依序为多囊肾出血（14．6％）、肾衰竭加重（10．1％）、透析相关问题（9．4％）、肾移植相关问题（8．3％）、进入终末期肾病（ESRD）准备替代治疗（8．O％）、泌尿系感染（6．4％）、发现肾衰竭（5_8％）、高血压（4．1％）、肾囊肿增大（3．7％）、发现多囊肾病（2．1％）、泌尿系结石（1．8％）及其他（10．4％）。（2）年轻患者多因多囊肾出血及发现多囊肾住院，随年龄增加，因透析相关问题住院者增加；中年患者多因腰腹痛住院。（3）男性多因肾衰竭加重、进入ESRD、肾移植相关问题、泌尿系结石而入院；女性多因腰腹痛、透析相关问题、泌尿系感染入院。（4）随时间变迁，因发现多囊肾、肾衰竭及多囊肾出血住院者比例显著减少，肾囊肿增大、肾衰竭加重住院者比例显著增加，伴高血压比例显著增加，而高血压未控制比例显著减少。结论ADPKD患者以40。60岁年龄组住院率最高，住院原因随年龄及性别不同而不同，并随年代变迁而改变。近十年来因。肾囊肿体积过大、肾衰竭加重住院患者比例显著增加，高血压发生率高于前10年，但高血压控制率较前提高。ADPKD防治重点在于寻找抑制肾囊肿增大的措施。Objective To analyze the causes of 652 hospitalizations in the patients with autosomal dominant polycystic kidney disease （ADPKD）. Methods The medical records of all ADPKD inpatients in our hospital from January 1, 1990 to December 31, 2010 were collected. The differences of hospitalization causes in different age, gender and period were analyzed. Results （1）In 552 hospitalizations, the most common cause was lumbar pain （15.2%）, followed by cystic bleeding （14.6%）, aggravating renal failure （10.1%）, dialysis-related problems （9.4%）, renal transplant related issues （8.3%）, renal replacement therapy for ESRD （8.0%）, urinary tract infection （6.4%）, end stage renal failure （5.8%）, hypertension （4.1%）, renal cyst volume enlargement （3.7%）, finding polycystic kidney disease （2.1%）, urinary lithiasis （1.8%） and others（10.4%）. （2）Younger patients were admitted into hospital because of polycystic kidney bleeding and finding PKD. With the increase of patients age, hospitalization due to dialysis-related problems increased, while many middle-aged patients were hospitalized because of back pain. （3）Male patients were admitted into hospital for aggravating renal failure, ESRD, kidney transplantation- related problems and urinary lithiasis, while female patients mainly for lumbar pain, dialysis-related problems and urinary tract infection. （4）The proportion was significantly reduced with time of finding PKD, renal failure and polycystie kidney bleeding, the proportion of renal cysts increasing and aggravating renal failure increased, there was a significant increase in the proportion of patients with hypertension, while a significant decrease in the proportion of patients with uncontrolled hypertension, and the average SBP was also significantly reduced. Conclusions The highest rate of hospitalization of ADPKD patients is in 40 to 60 age group. Cause of admission varies with age and gender, and changes with the change of time. Over the past decade, the pro

关 键 词：多囊肾病 常染色体显性 住院 肾囊肿 增大 肾衰竭 

分 类 号：R692.1[医药卫生—泌尿科学]