口服伊曲康唑治疗复发性外阴阴道念珠菌病的系统评价  

Efficacy of Itraconazole in the Treatment for Recurrent Vulvovaginal Candidiasis: A Systematic Review

作　　者：葛玮[1,2] 骆志成[1] 郑波波[3] 余炳前[1] 

机构地区：[1]兰州大学第二医院,甘肃兰州730030 [2]湖北省中山医院皮肤科,湖北武汉730030 [3]兰州大学循证医学中心,甘肃兰州730000

出　　处：《中国皮肤性病学杂志》2012年第11期1050-1052,1054,共4页The Chinese Journal of Dermatovenereology

基　　金：甘肃省自然科学基金项目(1010RJZA102);兰州大学第二医院院内基金(YJ2010-50)

摘　　要：目的评价不同疗程口服伊曲康唑胶囊治疗复发性外阴阴道念珠菌病的临床疗效与安全性。方法计算机检索中国期刊全文数据库(1994-20011.11),中国生物医学文献数据库(1978-20011.11),维普中文期刊数据库(1989-2011.11),PUBMED(1966-2011.11),EMBASE(1974-2011.11)和The Cochrane Library(2011.4)。纳入口服伊曲康唑治疗复发性外阴阴道念珠菌病的随机对照试验(RCT),并评价纳入研究的方法学质量,用Revman5.1软件进行统计学处理。结果纳入8个RCT,包括511例患者。Meta分析表明,短程冲击联合长期预防性间断服用伊曲康唑治疗复发性外阴阴道念珠菌病复发率低于单纯短程冲击疗法。结论与单纯短程口服伊曲康唑相比,联合长期间断预防服用伊曲康唑效果更优,复发率联合用药组更低。Objective To analyze the efficacy and recurrence rate of itraconazole in the treatment of the recurrent vul- vovaginal candidiasis. Methods We searched CNKI （1994 to November 2011 ）, the Chinese Biomedicine Database （CBM） （1978 to November 2011 ）, VIP （1989 to November 2011 ）, PubMed （1966 to January 2011 ）,EMbase （1974 to November2011 ） and the Cochrane Central Register of Controlled Trials （CEN- TRAL） （The Cochrane Library Issue 4,2011 ） to identify randomized controlled trials of different dosages/ course of treatment using itraconazole. Results Eight trials involving 511 patients were included in the effect analysis. Meta-analysis showed long-term preventive treatment was better than that short-term treat- ment. Conclusion Current evidence available shows that the efficacy in the long-term group is better,and the recurrence rate is lower.

关 键 词：伊曲康唑 复发性外阴阴道念珠菌病 系统评价 

分 类 号：R711.31[医药卫生—妇产科学]