乙型肝炎病毒核心相关抗原的监测及临床意义  

Clinical significance of monitoring hepatitis B virus core-related antigens

作　　者：刘成[1] 慕永平[2] 杨宗国[1] 陈晓蓉[1] 

机构地区：[1]上海市公共卫生临床中心,上海201508 [2]上海中医药大学附属曙光医院,上海201203

出　　处：《临床肝胆病杂志》2012年第10期793-796,共4页Journal of Clinical Hepatology

基　　金：上海市科学技术委员会医学引导类项目(10411963000)

摘　　要：监测乙型肝炎病毒核心相关抗原(HBcrAg),能有效预测核苷(酸)类药物抗病毒治疗后产生的病毒学反弹及耐药风险,具有重要的临床实用价值。Antiviral nucleot（s） ide analogs are the common therapy for patients with chronic hepatitis B （CHB） infection. HBV DNA in pe- ripheral blood is a sufficient and convenient indicator of treatment response and resistance; however, intrahepatie HBV DNA and covalently closed circular （ cce ） DNA are superior indicators of treatment failure at earlier stages. Unfortunately, monitoring of intrahepatic nucleic acids, including HBV DNA, cceDNA and RNA, is complicated and expensive. Since serum levels of hepatitis B virus core - related antigen （HBcrAg） correlate well with intrahepatie levels of HBV cccDNA it may represent an accurate and convenient indicator of treatment response and resistance in CHB patients. In this review, we discuss the recent research efforts to develop strategies for HBcrAg monitoring and to de- fine the underlying mechanisms of this clinical indicator system. Besides its promising clinical value, large - scale dynamic measures of HB- crAg in CHB patients may provide useful insights into the risk and causative factors of resistance to antiviral nucleot（s） analoge therapy.

关 键 词：肝炎核心抗原 乙型 肝炎病毒 乙型 肝炎 乙型 慢性 

分 类 号：R512.62[医药卫生—内科学]