家兔耳廓血肿模型的建立与应用初探  

Establishment of a model of rabbit auricular hematoma and its application

作　　者：韦文朗[1] 林辉[1] 韦炫羽[1] 邸星星[1] 刘泳铖[1] 

机构地区：[1]广西中医学院第一附属医院美肤激光整形美容科,南宁530003

出　　处：《中华医学美学美容杂志》2012年第5期376-378,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的建立家兔耳廓血肿模型．观察血肿的发生、吸收过程．研究血肿形成的组织层次和清除方法．及其对预防菜花耳畸形发生的意义。方法将10只健康新西兰兔随机分为A、B、C、D、E5组．A组为对照组，B～E组为实验组。实验组以重物从高处落下，撞击耳廓固定范围，晕复3～6次，直至形成较大血肿为止。对血肿形成后1h、4d和血肿基本吸收过程进行观察．制作病理切片观察组织层次，许行血肿引流实验。观察穿刺抽吸与切开引流的效果。以正常耳廓为对照组。结果实验组兔耳廓均有血肿形成．组织学显示：血肿位于皮肤与软骨之间，软骨内未见血肿；4d时可见新生毛细血管及成纤维细胞增生．綦本吸收时有纤维组织增生；切开血肿剥除．血凝块清除比较彻底。结论通过撞击易于制作耳廓血肿模型．血肿发生在皮下的结缔组织内，波动明显的血肿。应采用切开清除血凝块法治疗，有预防菜花状耳畸形之效果。Objective To establish a rabbit auricular hematoma model, to observe the process of production and absorption, and to study the location of hematoma and method of its removal. Meth- ods Ten heahh New Zealand rabbits were divided randomly into control group and experimental group. A weight was dropped onto particular locality of auricles 3-6 times until a big hematoma ap- peared. The pathological processes of hematoma were observed, and the hematoma was formed 1 hour and the hematoma was almost absorbed after 4 days. The drainage experiment was conducted to ob- serve the effect of needle aspiration or incision and drainage on the hematoma. Results All experimen- tal auricles formed hematoma. The histopathologicaI study showed that hematoma located between skin and cartilage, did not involve the cartilage. After 4 days. new-formed capillaries and fibroblasts were found, and then hematoma mostly absorbed; fibrous hyperplasia was been found. By cutting the hematoma, the blood clot could be thoroughly removed. Conclusions The auricular hematoma model can be established easily by striking with a heavy weight. Hematoma locates in subcutaneous connec- tive tissue. A large hematoma should be early removed for prevention of auricular deformity.

关 键 词：血肿模型 耳廓固定 家兔 成纤维细胞增生 血凝块清除 应用 血肿形成 纤维组织增生 

分 类 号：S858.292[农业科学—临床兽医学]